10779395

Source:http://linkedlifedata.com/resource/pubmed/id/10779395

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004927, umls-concept:C0017337, umls-concept:C0027923, umls-concept:C0031084, umls-concept:C0162340
pubmed:issue	1
pubmed:dateCreated	2000-7-11
pubmed:abstractText	Circadian clocks have been described in organisms ranging in complexity from unicells to mammals, in which they function to control daily rhythms in cellular activities and behavior. The significance of a detailed understanding of the clock can be appreciated by its ubiquity and its established involvement in human physiology, including endocrine function, sleep/wake cycles, psychiatric illness, and drug tolerances and effectiveness. Because the clock in all organisms is assembled within the cell and clock mechanisms are evolutionarily conserved, simple eukaryotes provide appropriate experimental systems for dissecting the clock. Significant progress has been made in deciphering the circadian system in Neurospora crassa using both genetic and molecular approaches, and Neurospora has contributed greatly to our understanding of (1) the feedback cycle that comprises a circadian oscillator, (2) the mechanisms by which the clock is kept in synchrony with the environment, and (3) the genes that reside in rhythmic output pathways. Importantly, the lessons learned in Neurospora are relevant to our understanding of clocks in higher eukaryotes.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM58529-01
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9607601
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1087-1845
pubmed:author	pubmed-author:Bell-PedersenDD
pubmed:copyrightInfo	Copyright 2000 Academic Press.
pubmed:issnType	Print
pubmed:volume	29
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1-18
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:10779395-Circadian Rhythm, pubmed-meshheading:10779395-Genes, Fungal, pubmed-meshheading:10779395-Neurospora crassa
pubmed:year	2000
pubmed:articleTitle	Understanding circadian rhythmicity in Neurospora crassa: from behavior to genes and back again.
pubmed:affiliation	Department of Biology, Texas A&M University, College Station, Texas 77843-3258, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't