| pubmed-article:10778983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10778983 | lifeskim:mentions | umls-concept:C0033229 | lld:lifeskim |
| pubmed-article:10778983 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:10778983 | lifeskim:mentions | umls-concept:C0012582 | lld:lifeskim |
| pubmed-article:10778983 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:10778983 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10778983 | lifeskim:mentions | umls-concept:C1660751 | lld:lifeskim |
| pubmed-article:10778983 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10778983 | pubmed:dateCreated | 2000-8-3 | lld:pubmed |
| pubmed-article:10778983 | pubmed:abstractText | Incubation of drug-resistant human tumor cells with a combination of prochlorperazine and dipyridamole has additive/synergistic effect on the cellular retention and cytotoxicity of doxorubicin. In patients administered a fixed dose of doxorubicin and prochlorperazine with escalating doses of dipyridamole, mean plasma levels of dipyridamole and prochlorperazine achieved were as high as 3.01 +/- 0.41 microm and 0.94 +/- 0.09 microm, respectively. Plasma samples from patients were analyzed in an in vitro assay to monitor the effect on the cellular retention of tritium-labeled daunorubicin in MDR1-transfected P388 cells. In 22 of 49 of the plasma samples analyzed, the daunorubicin in efflux blocking activity was one-half or greater than that of cells incubated with 12.5 microM verapamil, a well-known efflux blocker. These observations suggest that a combination of prochlorperazine and dipyridamole may enhance cellular doxorubicin retention by blocking efflux while reducing normal tissue toxicity and unwanted side effects in vivo. | lld:pubmed |
| pubmed-article:10778983 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10778983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10778983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10778983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10778983 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10778983 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:KrishanAA | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:SteinW DWD | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:MoeSS | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:FernandezHH | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:YimYY | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:SridharK SKS | lld:pubmed |
| pubmed-article:10778983 | pubmed:author | pubmed-author:LyubimovEE | lld:pubmed |
| pubmed-article:10778983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10778983 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:10778983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10778983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10778983 | pubmed:pagination | 1508-17 | lld:pubmed |
| pubmed-article:10778983 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10778983 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10778983 | pubmed:articleTitle | Synergistic effect of prochlorperazine and dipyridamole on the cellular retention and cytotoxicity of doxorubicin. | lld:pubmed |
| pubmed-article:10778983 | pubmed:affiliation | Department of Radiation Oncology, University of Miami Medical School and Sylvester Cancer Center, Florida 33136, USA. akrishan@mednet.med.miami.edu | lld:pubmed |
| pubmed-article:10778983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10778983 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10778983 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10778983 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:10778983 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10778983 | lld:pubmed |
