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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-6-26
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pubmed:abstractText |
HLA-DR4 is a primary disease association marker in type 1 diabetes mellitus (IDDM). We therefore analyzed the transmission of 228 DR4+ haplotypes in 183 families with an IDDM proband (95 from Germany and 88 from Belgium). In a separate case-control data set, we investigated the HLA-DRB1*04 and DQ allele distribution in 245 IDDM patients and 177 controls from Germany, all DR4 positive. HLA-DRB1 *0401 and *0402 linked to DQB1 *0302 were significantly more often transmitted to patients in the studied families (81% and 89%) in contrast to DRB1 *0401-DQB1 *0301 (33%). The case-control study of HLA-DQB1 *0302+ individuals revealed -DRB1 *0405 to be more frequent in patients with IDDM and HLA-DRB1 *0403 and -DRB1 *0404 to be less frequent. HLA-DQA1 *0102-DQB1 *0602 and -DQA1 *0501-DQB1 *0301 in trans complementation with DRB1 *0401-DQB1 *0302 were also significantly less frequent in IDDM patients (P<3x 10(-7) and P<0.02). In conclusion, HLA-DRB1 *0403 and -DQB1*0301 alleles in cis as well as protective DQ haplotypes in trans, confer dominant protection against IDDM in a German / Belgian population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0001-2815
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10777104-Adolescent,
pubmed-meshheading:10777104-Adult,
pubmed-meshheading:10777104-Belgium,
pubmed-meshheading:10777104-Case-Control Studies,
pubmed-meshheading:10777104-Child,
pubmed-meshheading:10777104-Child, Preschool,
pubmed-meshheading:10777104-Diabetes Mellitus, Type 1,
pubmed-meshheading:10777104-Disease Susceptibility,
pubmed-meshheading:10777104-Female,
pubmed-meshheading:10777104-Genetic Predisposition to Disease,
pubmed-meshheading:10777104-Germany,
pubmed-meshheading:10777104-HLA-DQ Antigens,
pubmed-meshheading:10777104-HLA-DQ alpha-Chains,
pubmed-meshheading:10777104-HLA-DQ beta-Chains,
pubmed-meshheading:10777104-HLA-DR Antigens,
pubmed-meshheading:10777104-HLA-DRB1 Chains,
pubmed-meshheading:10777104-Humans,
pubmed-meshheading:10777104-Infant,
pubmed-meshheading:10777104-Male
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pubmed:year |
2000
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pubmed:articleTitle |
HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.
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pubmed:affiliation |
Medical Department I, Center of Internal Medicine, Johan Wolfgang Goethe-University Hospital, Frankfurt/Main, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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