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rdf:type |
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lifeskim:mentions |
umls-concept:C0003261,
umls-concept:C0025010,
umls-concept:C0039195,
umls-concept:C0072844,
umls-concept:C0205263,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1515655,
umls-concept:C1521827,
umls-concept:C1524073,
umls-concept:C1533691,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1707391,
umls-concept:C1879547,
umls-concept:C1998793
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pubmed:issue |
23
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pubmed:dateCreated |
2000-8-24
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pubmed:abstractText |
Semipurified Quil A and purified Quil A were used to prepare well-characterized subunit vaccine candidates against measles. Variation in the relative amounts of the measles virus (MV) fusion (F) protein, Quil A-components and lipids did not influence induction of antibody responses in mice, but had a pronounced effect on the capacity to induce cytotoxic T cell (CTL) activity of a CD8(+) MV F-protein specific human T cell clone in vitro. A characteristic MV iscom preparation based on the combined use of HPLC-purified Quil A-components QA-3 and QA-22 (QA-3/22) efficiently induced CTL activity in vitro. Comparable results were obtained by mixing beta-propiolactone inactivated MV with iscom-matrix QA-3/22 or free QA-22. On the basis of the data presented it was concluded that these three preparations are interesting MV vaccine candidates for further evaluation in pre-clinical experiments in a primate model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/ISCOMs,
http://linkedlifedata.com/resource/pubmed/chemical/Measles Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Propiolactone,
http://linkedlifedata.com/resource/pubmed/chemical/Quil A,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Attenuated,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/hemagglutinin protein G, measles...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:BoerKK,
pubmed-author:DalsgaardKK,
pubmed-author:KerstenG FGF,
pubmed-author:MulderP GPG,
pubmed-author:OsterhausA DAD,
pubmed-author:RohollP JPJ,
pubmed-author:SpiekstraAA,
pubmed-author:StittelaarK JKJ,
pubmed-author:de VriesPP,
pubmed-author:van AlphenLL,
pubmed-author:van den DobbelsteenGG
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2482-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10775782-Adjuvants, Immunologic,
pubmed-meshheading:10775782-Animals,
pubmed-meshheading:10775782-Antibodies, Viral,
pubmed-meshheading:10775782-Cells, Cultured,
pubmed-meshheading:10775782-Cercopithecus aethiops,
pubmed-meshheading:10775782-Chromatography, High Pressure Liquid,
pubmed-meshheading:10775782-Cytotoxicity, Immunologic,
pubmed-meshheading:10775782-Hemagglutinins, Viral,
pubmed-meshheading:10775782-Humans,
pubmed-meshheading:10775782-ISCOMs,
pubmed-meshheading:10775782-Lymphocyte Activation,
pubmed-meshheading:10775782-Measles Vaccine,
pubmed-meshheading:10775782-Measles virus,
pubmed-meshheading:10775782-Mice,
pubmed-meshheading:10775782-Mice, Inbred BALB C,
pubmed-meshheading:10775782-Microscopy, Electron,
pubmed-meshheading:10775782-Propiolactone,
pubmed-meshheading:10775782-Saponins,
pubmed-meshheading:10775782-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10775782-Vaccination,
pubmed-meshheading:10775782-Vaccines, Attenuated,
pubmed-meshheading:10775782-Vero Cells,
pubmed-meshheading:10775782-Viral Fusion Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
In vivo antibody response and in vitro CTL activation induced by selected measles vaccine candidates, prepared with purified Quil A components.
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pubmed:affiliation |
Laboratory for Vaccine Research, Institute of Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study
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