| pubmed-article:10775602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10775602 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10775602 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10775602 | pubmed:dateCreated | 2000-5-11 | lld:pubmed |
| pubmed-article:10775602 | pubmed:abstractText | Human immunodeficiency virus (HIV)-positive individuals express elevated levels of interleukin-8 (IL-8), which is believed to be responsible for some of the clinical manifestations occurring during AIDS. We report here that virion-derived HIV type 1 (HIV-1) protein R (Vpr) increased IL-8 expression in primary T cells and macrophages, as well as in the T-cell line Jurkat, the monocytic cell line U937, and the epithelial cell line A549. Vpr appeared to increase IL-8 expression and IL-8 promoter activity by activating transcription factors NF-kappaB and NF-IL-6. Elevated Vpr was also shown to increase transcription of the NF-kappaB and NF-IL-6 enhancer-containing viral promoters for HIV, cytomegalovirus, and simian virus 40, as well as increase the expression of IL-6 and IL-10 in primary macrophages and in A549 cells, tumor necrosis factor alpha expression in primary T cells, and IL-6 and gamma interferon expression in U937 cells. These results suggest a new role for Vpr in the pathogenesis of HIV infection, namely, the activation of transcription factors NF-IL-6 and NF-kappaB. | lld:pubmed |
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| pubmed-article:10775602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10775602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10775602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10775602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10775602 | pubmed:month | May | lld:pubmed |
| pubmed-article:10775602 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10775602 | pubmed:author | pubmed-author:TannerJ EJE | lld:pubmed |
| pubmed-article:10775602 | pubmed:author | pubmed-author:RouxPP | lld:pubmed |
| pubmed-article:10775602 | pubmed:author | pubmed-author:CohenE AEA | lld:pubmed |
| pubmed-article:10775602 | pubmed:author | pubmed-author:AlfieriCC | lld:pubmed |
| pubmed-article:10775602 | pubmed:author | pubmed-author:HrimechMM | lld:pubmed |
| pubmed-article:10775602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10775602 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10775602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10775602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10775602 | pubmed:pagination | 4658-65 | lld:pubmed |
| pubmed-article:10775602 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10775602 | pubmed:meshHeading | pubmed-meshheading:10775602... | lld:pubmed |
