| pubmed-article:10775267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C0334459 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C1424876 | lld:lifeskim |
| pubmed-article:10775267 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10775267 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10775267 | pubmed:dateCreated | 2000-6-13 | lld:pubmed |
| pubmed-article:10775267 | pubmed:abstractText | The TEL-TRKC fusion is expressed as a consequence of t(12;15)(p13;q25), and is associated with two human cancers: congenital fibrosarcoma and acute myelogenous leukemia (AML). We report that the T/T(F) and T/T(L) fusion variants associated with congenital fibrosarcoma and AML, respectively, are constitutively tyrosine phosphorylated, and confer factor-independent growth to the murine hematopoietic cell line Ba/F3. Retroviral transduction of T/T(L) causes a rapidly fatal myeloproliferative disease in a murine bone marrow transplant (BMT) model, whereas T/T(F) causes a long-latency, pre-B-cell lymphoblastic lymphoma. TEL-TRKC variants are potent activators of the MAP kinase pathway, but neither variant activates Stat5 or other Stat family members. T/T(L), but not T/T(F), induces tyrosine phosphorylation of phospholipase Cgamma (PLCgamma), phosphoinositol-3 kinase and SHC. However, mutation analysis demonstrates that PLCgamma tyrosine phos phorylation by T/T(L) is dispensable for induction of the myeloproliferative phenotype by T/T(L). Collectively, these data demonstrate that the TEL-TRKC fusion variants are oncoproteins that activate the MAP kinase pathway, and do not require activation of either PLCgamma or Stat5 for efficient induction of a myeloproliferative phenotype in the murine BMT model. | lld:pubmed |
| pubmed-article:10775267 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10775267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10775267 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10775267 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:WilliamsI RIR | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:GillilandD... | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:AsterJ CJC | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:CajaRR | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:LieAA | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:KutokJJ | lld:pubmed |
| pubmed-article:10775267 | pubmed:author | pubmed-author:SchwallerJJ | lld:pubmed |
| pubmed-article:10775267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10775267 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10775267 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10775267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10775267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10775267 | pubmed:pagination | 1827-38 | lld:pubmed |
| pubmed-article:10775267 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10775267 | pubmed:meshHeading | pubmed-meshheading:10775267... | lld:pubmed |
| pubmed-article:10775267 | pubmed:meshHeading | pubmed-meshheading:10775267... | lld:pubmed |
