Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2000-6-13
pubmed:abstractText
The TEL-TRKC fusion is expressed as a consequence of t(12;15)(p13;q25), and is associated with two human cancers: congenital fibrosarcoma and acute myelogenous leukemia (AML). We report that the T/T(F) and T/T(L) fusion variants associated with congenital fibrosarcoma and AML, respectively, are constitutively tyrosine phosphorylated, and confer factor-independent growth to the murine hematopoietic cell line Ba/F3. Retroviral transduction of T/T(L) causes a rapidly fatal myeloproliferative disease in a murine bone marrow transplant (BMT) model, whereas T/T(F) causes a long-latency, pre-B-cell lymphoblastic lymphoma. TEL-TRKC variants are potent activators of the MAP kinase pathway, but neither variant activates Stat5 or other Stat family members. T/T(L), but not T/T(F), induces tyrosine phosphorylation of phospholipase Cgamma (PLCgamma), phosphoinositol-3 kinase and SHC. However, mutation analysis demonstrates that PLCgamma tyrosine phos phorylation by T/T(L) is dispensable for induction of the myeloproliferative phenotype by T/T(L). Collectively, these data demonstrate that the TEL-TRKC fusion variants are oncoproteins that activate the MAP kinase pathway, and do not require activation of either PLCgamma or Stat5 for efficient induction of a myeloproliferative phenotype in the murine BMT model.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-10361113, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-10428802, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-1281417, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-1649702, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-1653651, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-1742028, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-1850549, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-2406902, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-2440107, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-2725497, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-7657612, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-7805037, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-7911739, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8112292, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8122112, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8145824, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8155326, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8156997, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8168137, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8344249, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8384556, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8402896, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8425181, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8494647, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8621434, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8754809, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8808688, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8833445, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8833451, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8940193, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-8962143, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9009269, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9069267, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9326218, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9345013, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9360930, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9373237, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9376569, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9389713, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9425908, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9462753, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9616134, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9684923, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9716603, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9736611, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9811336, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9823307, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9949179, http://linkedlifedata.com/resource/pubmed/commentcorrection/10775267-9973222
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase C gamma, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkC, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases, http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1827-38
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
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