| pubmed-article:10775035 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0007952 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10775035 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10775035 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10775035 | pubmed:dateCreated | 2000-6-9 | lld:pubmed |
| pubmed-article:10775035 | pubmed:abstractText | The c-Raf-1 kinase is a downstream effector of Ras signaling. Both proteins are highly oncogenic when they are mutationally activated, but only the Ras GTPase is frequently mutated in naturally occurring tumors. Although the c-Raf-1 protein was found to be amplified in different lung cancer cell lines, overexpression of the wild-type c-Raf-1 protein was shown to be insufficient to transform cultured cells. Here we have addressed the question of whether overexpression of the wild-type c-Raf-1 kinase can induce lung cancer in mice. We show that lung-targeted expression of oncogenically activated or wild-type c-Raf-1 proteins induces morphologically indistinguishable lung adenomas in transgenic mice. Compared with mice transgenic for the activated c-Raf-1-BxB, tumor development is delayed and occurs at a lower incidence in wild-type c-Raf-1 transgenic mice. Our studies show that the c-Raf-1 expression level is a critical parameter in tumor development and should be analyzed in more detail to evaluate its potential in the induction of cancer. | lld:pubmed |
| pubmed-article:10775035 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10775035 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775035 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10775035 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775035 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10775035 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10775035 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10775035 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10775035 | pubmed:issn | 1044-9523 | lld:pubmed |
| pubmed-article:10775035 | pubmed:author | pubmed-author:RappU RUR | lld:pubmed |
| pubmed-article:10775035 | pubmed:author | pubmed-author:FedorovL MLM | lld:pubmed |
| pubmed-article:10775035 | pubmed:author | pubmed-author:SiefkenRR | lld:pubmed |
| pubmed-article:10775035 | pubmed:author | pubmed-author:PapadopoulouZ... | lld:pubmed |
| pubmed-article:10775035 | pubmed:author | pubmed-author:KerkhoffEE | lld:pubmed |
| pubmed-article:10775035 | pubmed:author | pubmed-author:WalterA OAO | lld:pubmed |
| pubmed-article:10775035 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10775035 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10775035 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10775035 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10775035 | pubmed:pagination | 185-90 | lld:pubmed |
| pubmed-article:10775035 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10775035 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10775035 | pubmed:articleTitle | Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. | lld:pubmed |
| pubmed-article:10775035 | pubmed:affiliation | Institut für medizinische Strahlenkunde und Zellforschung, Universität Würzburg, Germany. | lld:pubmed |
| pubmed-article:10775035 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10775035 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:110157 | entrezgene:pubmed | pubmed-article:10775035 | lld:entrezgene |
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