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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-7-13
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pubmed:abstractText |
The ETS family member Tel is rearranged in human leukemia of both myeloid and lymphoid origin while the ETS member Fli-1 is insertionally activated in Friend erythroleukemia in mice and is translocated to the EWS locus in Ewing's sarcoma. In previous studies we demonstrated that Tel binds to Fli-1 and blocks transactivation of megakaryocytic promoters by Fli-1. In this study we demonstrate that expression of Fli-1 in the leukemia cell line K562 induces a megakaryocytic phenotype and the expression of the platelet markers GPIX, GP1balpha, and GPIIb. Introduction of Tel blocked the megakaryocytic phenotype induced by Fli-1, suggesting a biological correlation to the biochemical interaction of Tel and Fli-1 reported previously.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Glycoprotein GPIIb-IIIa...,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Glycoprotein GPIb-IX...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-fli-1,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1079-9796
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-90
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10772879-Biological Markers,
pubmed-meshheading:10772879-Blotting, Western,
pubmed-meshheading:10772879-Cloning, Molecular,
pubmed-meshheading:10772879-DNA-Binding Proteins,
pubmed-meshheading:10772879-Gene Expression Regulation,
pubmed-meshheading:10772879-Hematopoietic Stem Cells,
pubmed-meshheading:10772879-Humans,
pubmed-meshheading:10772879-K562 Cells,
pubmed-meshheading:10772879-Megakaryocytes,
pubmed-meshheading:10772879-Multigene Family,
pubmed-meshheading:10772879-Phenotype,
pubmed-meshheading:10772879-Platelet Glycoprotein GPIIb-IIIa Complex,
pubmed-meshheading:10772879-Platelet Glycoprotein GPIb-IX Complex,
pubmed-meshheading:10772879-Proto-Oncogene Protein c-fli-1,
pubmed-meshheading:10772879-Proto-Oncogene Proteins,
pubmed-meshheading:10772879-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:10772879-Repressor Proteins,
pubmed-meshheading:10772879-Trans-Activators,
pubmed-meshheading:10772879-Transcription Factors,
pubmed-meshheading:10772879-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
The ETS family member Tel antagonizes the Fli-1 phenotype in hematopoietic cells.
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pubmed:affiliation |
Medical Research Service, VA Puget Sound Health Care System, Seattle, Washington 98108, USA.
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pubmed:publicationType |
Journal Article
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