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rdf:type |
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lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0007634,
umls-concept:C0013081,
umls-concept:C0040845,
umls-concept:C0087111,
umls-concept:C0205251,
umls-concept:C0205263,
umls-concept:C0249197,
umls-concept:C0288472,
umls-concept:C0332281,
umls-concept:C1420626
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pubmed:issue |
2-3
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pubmed:dateCreated |
2000-6-29
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pubmed:abstractText |
The effect of nontoxic, low concentrations (10(-8) M) of retinoic acid (RA) for a relatively long time (28 days) on a Kirsten ras-virus transformed cell line (Ki-SVC1), derived from the rat seminal vesicle epithelium, was investigated. In these experimental conditions, the cell treatment with RA induced a decrease of the proliferation rate, apoptosis and a marked reduction of both anchorage-independent growth and tumorigenicity. These biological responses were either preceded or associated with important changes in adenylate cyclase/protein kinase C signaling pathways, the activation of important apoptosis-linked genes and a marked decrease of the v-Ki-ras p21 protein. The significance of these findings is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
1496
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-95
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10771097-Adenylate Cyclase,
pubmed-meshheading:10771097-Animals,
pubmed-meshheading:10771097-Antineoplastic Agents,
pubmed-meshheading:10771097-Apoptosis,
pubmed-meshheading:10771097-Cell Division,
pubmed-meshheading:10771097-Cell Line, Transformed,
pubmed-meshheading:10771097-Cell Membrane,
pubmed-meshheading:10771097-Cyclic AMP,
pubmed-meshheading:10771097-Cytosol,
pubmed-meshheading:10771097-Dose-Response Relationship, Drug,
pubmed-meshheading:10771097-Down-Regulation,
pubmed-meshheading:10771097-Hemangiosarcoma,
pubmed-meshheading:10771097-Neoplasm Transplantation,
pubmed-meshheading:10771097-Protein Kinase C,
pubmed-meshheading:10771097-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:10771097-RNA, Messenger,
pubmed-meshheading:10771097-Rats,
pubmed-meshheading:10771097-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10771097-Signal Transduction,
pubmed-meshheading:10771097-Tretinoin
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pubmed:year |
2000
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pubmed:articleTitle |
Treatment of v-Ki-ras-transformed SVC1 cells with low retinoic acid induces malignancy reversion associated with ras p21 down-regulation.
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pubmed:affiliation |
Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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