Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-6-13
pubmed:abstractText
Our previous study showed that gamma interferon (IFN-gamma), a T-helper 1 (Th1)-type cytokine, plays a detrimental role in Staphylococcus aureus infection in mice. In this study, the role of Th2-type cytokines such as interleukin-4 (IL-4) and IL-10 in S. aureus infection was investigated. IL-10 mRNA was induced in parallel with IFN-gamma in the spleens and kidneys of mice during S. aureus infection, whereas IL-4 mRNA was induced in the spleens but not in the kidneys of these animals. Spleen cells obtained from S. aureus-infected mice produced lower titers of IFN-gamma and higher titers of IL-4 and IL-10 in response to heat-killed S. aureus than did those from uninfected mice. Administration of anti-IL-4 monoclonal antibody (MAb) or anti-IL-10 MAb inhibited the elimination of S. aureus cells from the kidneys of mice. IFN-gamma mRNA expression was enhanced in the spleens of anti-IL-4 MAb- or anti-IL-10 MAb-treated mice and also in the kidneys of anti-IL-4 MAb-treated animals. Next, we evaluated the role of IFN-gamma in S. aureus infection in IFN-gamma(-/-) mice. An increase in survival rates, a decrease in bacterial numbers in the kidneys, and an amelioration of histologic abnormalities in these organs were observed in IFN-gamma(-/-) mice compared with those in IFN-gamma(+/+) mice. Administration of MAb against IL-4 or IL-10 failed to affect bacterial growth in the spleens and kidneys of IFN-gamma(-/-) mice irrespective of the expression of Th2 response. These results suggest that S. aureus infection induced a Th2 response and that IL-4 and IL-10 might play a protective role through the regulation of IFN-gamma in S. aureus infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-10354370, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-10358772, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-10458752, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-1385868, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-1535368, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-1602140, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-1833466, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-2112583, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-2521244, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7499861, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7593621, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7608550, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7869043, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7890367, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7908304, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7912089, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-7915740, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8163930, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8300208, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8386517, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8426124, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8459215, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8514420, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8606087, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-8893001, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9036973, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9041936, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9233639, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9488390, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9536122, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9565382, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9590259, http://linkedlifedata.com/resource/pubmed/commentcorrection/10768926-9783259
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2424-30
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Interleukin-4 and interleukin-10 are involved in host resistance to Staphylococcus aureus infection through regulation of gamma interferon.
pubmed:affiliation
Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't