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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-4-27
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pubmed:abstractText |
This study was undertaken to test the hypothesis that topiramate (TPM) exerts a negative modulatory effect on some types of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA)/kainate receptors by binding to the site at which protein kinase A (PKA) phosphorylates the receptor-channel complex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidine,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/domoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/topiramate
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pubmed:status |
MEDLINE
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S48-51
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10768301-Animals,
pubmed-meshheading:10768301-Anticonvulsants,
pubmed-meshheading:10768301-Carbon Radioisotopes,
pubmed-meshheading:10768301-Cell Line,
pubmed-meshheading:10768301-Cricetinae,
pubmed-meshheading:10768301-Cyclic AMP,
pubmed-meshheading:10768301-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10768301-Forskolin,
pubmed-meshheading:10768301-Fructose,
pubmed-meshheading:10768301-Guanidine,
pubmed-meshheading:10768301-Kainic Acid,
pubmed-meshheading:10768301-Kidney,
pubmed-meshheading:10768301-Phosphorylation,
pubmed-meshheading:10768301-Receptors, AMPA,
pubmed-meshheading:10768301-Receptors, Glutamate,
pubmed-meshheading:10768301-Receptors, Kainic Acid,
pubmed-meshheading:10768301-Scintillation Counting,
pubmed-meshheading:10768301-Transfection
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pubmed:year |
2000
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pubmed:articleTitle |
Effects of topiramate on kainate- and domoate-activated [14C]guanidinium ion flux through GluR6 channels in transfected BHK cells using Cytostar-T scintillating microplates.
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pubmed:affiliation |
Nycomed Amersham plc, Cardiff, United Kingdom.
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pubmed:publicationType |
Journal Article
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