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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-5-31
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pubmed:databankReference |
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pubmed:abstractText |
There are several mechanisms for the determination of sex. Sexual behaviour is part of the sex-determination cascade, and in Drosophila melanogaster male courtship is controlled in part by the fruitless gene. As part of a study of sexual behaviour in Hawaiian Drosophila, we have cloned the neural sex-determination gene fru from the Hawaiian picture-wing species Drosophila heteroneura. The fru gene has at least seven exons covering a region of 18kb and encodes three transcripts, fruA, fruB and fruC. Each transcript encodes a single ORF of 841, 678 and 691aa, respectively. The FRUA and FRUB proteins have a BTB protein-protein-binding domain and two zinc finger-like domains and are well conserved with the D. melanogaster proteins. The FRUC protein has a BTB domain but no zinc finger-like domains. The fru gene is expressed in 1-7 day old adult males as a 5.1kb transcript. This transcript is not seen in adult females, so the fru gene has a different pattern of sex-differential expression in the Hawaiian Drosophila compared with D. melanogaster.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
246
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10767535-Alternative Splicing,
pubmed-meshheading:10767535-Amino Acid Sequence,
pubmed-meshheading:10767535-Animals,
pubmed-meshheading:10767535-Blotting, Northern,
pubmed-meshheading:10767535-DNA,
pubmed-meshheading:10767535-DNA, Complementary,
pubmed-meshheading:10767535-Drosophila,
pubmed-meshheading:10767535-Drosophila Proteins,
pubmed-meshheading:10767535-Exons,
pubmed-meshheading:10767535-Female,
pubmed-meshheading:10767535-Gene Expression Regulation,
pubmed-meshheading:10767535-Genes, Insect,
pubmed-meshheading:10767535-Introns,
pubmed-meshheading:10767535-Male,
pubmed-meshheading:10767535-Molecular Sequence Data,
pubmed-meshheading:10767535-Nerve Tissue Proteins,
pubmed-meshheading:10767535-Protein Isoforms,
pubmed-meshheading:10767535-RNA,
pubmed-meshheading:10767535-Sequence Alignment,
pubmed-meshheading:10767535-Sequence Analysis, DNA,
pubmed-meshheading:10767535-Sequence Homology, Amino Acid,
pubmed-meshheading:10767535-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura.
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pubmed:affiliation |
Yamamoto Behavior Genes Project, ERATO, Center for Conservation Research and Training, University of Hawaii at Manoa, 3050 Maile Way, Gilmore 408, Honolulu, HI 96822, USA. davist2@cardiff.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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