Source:http://linkedlifedata.com/resource/pubmed/id/10766405
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-5-23
|
| pubmed:abstractText |
We investigated the relationship between plasma levels of metabolic and fibrinolytic variables in 163 fasted patients attending a lipid clinic. Of these patients, 118 had hypertriglyceridaemia (HTG) and 45 had normotriglyceridaemia (NTG). In HTG, basal fibrinolytic activity, ie tissue plasminogen activator (t-PA) activity, was impaired as a result of high plasminogen activator inhibitor type 1 (PAI-1) antigen and activity. Multiple stepwise regression analysis identified insulin and triglyceride levels as independent determinants of plasma PAI-1 levels (R2 = 0.18; P = 0.0001). When the patients were stratified into tertiles according to their levels of triglyceride and insulin, PAI-1 antigen levels were found to increase with rising levels of triglyceride in each insulin tertile. In contrast, the increase of PAI-1 with rising insulin levels was evident in the highest triglyceride tertile. In addition, subjects in the lowest tertile of both triglyceride and insulin had the lowest PAI-1 antigen levels, and subjects in the highest tertile of both triglyceride and insulin had the highest levels of PAI-1. Both basal and stimulated levels of t-PA antigen were significantly higher in HTG than in NTG. Multiple stepwise regression analysis identified triglyceride level as the sole major determinant of t-PA antigen levels (R2 = 0.13; P = 0.00003). The observation that both insulin and triglycerides correlate with PAI-1, whereas triglycerides were involved only in the increased secretion of t-PA, suggests that these two proteins are regulated by different mechanisms.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0785-3890
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
134-41
|
| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10766405-Adolescent,
pubmed-meshheading:10766405-Adult,
pubmed-meshheading:10766405-Aged,
pubmed-meshheading:10766405-Ambulatory Care Facilities,
pubmed-meshheading:10766405-Female,
pubmed-meshheading:10766405-Humans,
pubmed-meshheading:10766405-Hyperlipidemias,
pubmed-meshheading:10766405-Insulin,
pubmed-meshheading:10766405-Male,
pubmed-meshheading:10766405-Middle Aged,
pubmed-meshheading:10766405-Multivariate Analysis,
pubmed-meshheading:10766405-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:10766405-Plasminogen Activators,
pubmed-meshheading:10766405-Reference Values,
pubmed-meshheading:10766405-Regression Analysis,
pubmed-meshheading:10766405-Sensitivity and Specificity,
pubmed-meshheading:10766405-Tissue Plasminogen Activator,
pubmed-meshheading:10766405-Triglycerides
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Relationship between fibrinolytic and metabolic variables: a study in patients attending a lipid clinic.
|
| pubmed:affiliation |
Institute of Pharmacological Sciences and E Grossi Paoletti Center, University of Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|