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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-6-13
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pubmed:abstractText |
In the present study, mutations or protein expression of p53, bcl-2 and bax are reported in 13 non-Hodgkin's B-cell lymphomas of the head and neck. Nine of 13 cases (69.2%) expressed p53 protein and 7 (53.8%) showed gene mutations. On comparing the results of immunostaining and SSCP analysis, there were two cases showing discrepancies between the p53 protein expression and gene mutations. Bcl-2 protein expression was observed in only two cases of follicular lymphoma. On the other hand, bax protein was detected in all 13 cases. One case with mutated bax gene showed a lower expression with a reduced frequency of bax-positive cells than the other 12. These results suggest that inactivation of p53 may be closely related to development and/or progression of these NHLs, and that bcl-2 and bax protein may not have a role.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0904-2512
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
180-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10766396-Adolescent,
pubmed-meshheading:10766396-Adult,
pubmed-meshheading:10766396-Aged,
pubmed-meshheading:10766396-Aged, 80 and over,
pubmed-meshheading:10766396-Burkitt Lymphoma,
pubmed-meshheading:10766396-Child,
pubmed-meshheading:10766396-Disease Progression,
pubmed-meshheading:10766396-Female,
pubmed-meshheading:10766396-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10766396-Gene Silencing,
pubmed-meshheading:10766396-Genes, p53,
pubmed-meshheading:10766396-Head and Neck Neoplasms,
pubmed-meshheading:10766396-Humans,
pubmed-meshheading:10766396-Immunoenzyme Techniques,
pubmed-meshheading:10766396-Lymphoma, B-Cell,
pubmed-meshheading:10766396-Lymphoma, Follicular,
pubmed-meshheading:10766396-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:10766396-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10766396-Male,
pubmed-meshheading:10766396-Middle Aged,
pubmed-meshheading:10766396-Mutation,
pubmed-meshheading:10766396-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:10766396-Proto-Oncogene Proteins,
pubmed-meshheading:10766396-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10766396-Tumor Suppressor Protein p53,
pubmed-meshheading:10766396-bcl-2-Associated X Protein
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pubmed:year |
2000
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pubmed:articleTitle |
p53, bcl-2 and bax abnormalities in non-Hodgkin's lymphomas of the head and neck.
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pubmed:affiliation |
Department of Oral and Maxillofacial Surgery II, Hiroshima University School of Dentistry, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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