Source:http://linkedlifedata.com/resource/pubmed/id/10763843
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2000-7-10
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| pubmed:abstractText |
We report a 14-year-old girl with primary amenorrhea and virilization. The chromosomal analysis showed a normal 46,XX female karyotype and the hormonal assays disclosed high serum levels of testosterone (T): 450 ng/dL (normal 5-90), dehidroepiandrosterone-sulfate (DHEA-S): 690 microg/dL (normal 30-450) and 17-hydroxiprogesterone (17-OHP) >20 ng/mL (normal <2). A pelvic ultrasound disclosed a small uterus and bilateral enlargement of the ovaries, a computed axial tomographic scan of the abdomen identified a large right mass in the adrenal gland and a norcholesterol-I 131 adrenal gammagraphy revealed a functional adrenal tumor. The histological analysis of the surgical removed tumor revealed and adrenal adenoma. After surgery, a steep decline to normal serum levels of T and DHEA-S was observed, remaining an elevated level of 17-OHP: 5.4 ng/mL. During the first three months of follow up, the hirsutism declined sharply and spontaneous mammary development occurred, remaining elevated the 17-OHP serum level: 4.8 ng/mL. Prednisone 5 mg/day, was initiated decreasing the 17-OHP to normal level: 1.4 ng/mL, appearing the menarche followed by cyclical menses. One year after surgery, prednisone was withdrawn during one week, and an ACTH test and HLA typing were done, disclosing a 17-OHP response of an heterozygote for adrenal hyperplasia, and identifying B65 a subtype of B14, and DR1, that are frequently associated to adrenal hyperplasia. Previous reports have informed silent adrenal tumors associated to adrenal hyperplasia, but this is the first report of a functional adrenal tumor associated to adrenal hyperplasia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0932-0067
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
263
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
134-6
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10763843-Adenoma,
pubmed-meshheading:10763843-Adolescent,
pubmed-meshheading:10763843-Adrenal Gland Neoplasms,
pubmed-meshheading:10763843-Adrenal Hyperplasia, Congenital,
pubmed-meshheading:10763843-Amenorrhea,
pubmed-meshheading:10763843-Female,
pubmed-meshheading:10763843-Heterozygote Detection,
pubmed-meshheading:10763843-Humans,
pubmed-meshheading:10763843-Karyotyping,
pubmed-meshheading:10763843-Tomography, X-Ray Computed,
pubmed-meshheading:10763843-Virilism
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Virilizing adrenal adenoma and primary amenorrhea in a girl with adrenal hyperplasia.
|
| pubmed:affiliation |
Department of Endocrinology, Hospital de Gineco-Obstetricia, Monterrey, NL, México. gefor@sysop.com.mx
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| pubmed:publicationType |
Journal Article
|