| pubmed-article:10762358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10762358 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:10762358 | lifeskim:mentions | umls-concept:C0887882 | lld:lifeskim |
| pubmed-article:10762358 | lifeskim:mentions | umls-concept:C0144255 | lld:lifeskim |
| pubmed-article:10762358 | lifeskim:mentions | umls-concept:C0178766 | lld:lifeskim |
| pubmed-article:10762358 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10762358 | pubmed:dateCreated | 2000-6-21 | lld:pubmed |
| pubmed-article:10762358 | pubmed:abstractText | Mammalian synaptotagmins constitute a multigene family of at least 11 membrane proteins. We have characterized synaptotagmin IV using antibodies directed against the C2A domain of the protein. Antibodies reacted specifically with a protein band that migrated as a 41-44 kDa doublet. Synaptotagmin IV expression was regulated throughout development. A strong decrease in the amount detected by Western blotting occurred between postnatal day 5 and adulthood, in agreement with studies on the expression of synaptotagmin IV transcripts. In subcellular fractionation, synaptotagmin IV was not detected in the synaptic vesicle-enriched fraction. Immunofluorescence microscopy was concordant with this finding. In 6-day-old rat cerebellum and cultured hippocampal neurons the subcellular distribution of synaptotagmin IV was clearly different from that of synaptotagmin I. Synaptotagmin IV displayed a punctate non-polarized distribution on neuronal extensions, whereas synaptotagmin I staining was essentially synaptic. Synaptotagmin IV staining was also observed in the soma in strong perinuclear fluorescent puncta superimposed on that of Golgi/TGN markers. Furthermore, synaptotagmin IV was seen in the proximal part of the growth cone domain and not in the microfilament-rich region which includes filopodia. Co-localizations with the adhesion molecules vinculin and zyxin at the proximal part of growth cones were observed. Synaptotagmin IV may thus be involved in the regulation of specific membrane-trafficking pathways during brain development. | lld:pubmed |
| pubmed-article:10762358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10762358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10762358 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10762358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10762358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10762358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10762358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10762358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10762358 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10762358 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:FukudaMM | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:GarridoJJ | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:SeagarMM | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:BertonFF | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:CornerTT | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:DargentBB | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:MarquèzeBB | lld:pubmed |
| pubmed-article:10762358 | pubmed:author | pubmed-author:IborraCC | lld:pubmed |
| pubmed-article:10762358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10762358 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10762358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10762358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10762358 | pubmed:pagination | 1294-302 | lld:pubmed |
| pubmed-article:10762358 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10762358 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10762358 | pubmed:articleTitle | Synaptotagmin I and IV define distinct populations of neuronal transport vesicles. | lld:pubmed |
| pubmed-article:10762358 | pubmed:affiliation | INSERM U 464, Institut Fédératif Jean Roche, Université de la Méditerranée, Faculté de Médecine, Marseille Cedex 20, France. | lld:pubmed |
| pubmed-article:10762358 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10762358 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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