Source:http://linkedlifedata.com/resource/pubmed/id/10762298
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2000-5-18
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| pubmed:abstractText |
Haemolytic uraemic syndrome (HUS) associated with Escherichia coli O157:H7 is the commonest cause of acute renal failure (ARF) in childhood. Production of verotoxin by the organism is pivotal in the pathogenesis of the disease. Verotoxin binds to a receptor on blood and endothelial cells, expressed as the P1 blood group antigen on red blood cells. A protective effect of the P1 phenotype has been proposed in this disease. This study investigates prognostic factors and the relationship between outcome and P1 phenotype in 27 cases of diarrhoea-associated HUS. A poor outcome as defined by the presence of chronic renal failure (CRF), hypertension or proteinuria on 6 month follow-up was associated with the age of the patient at presentation and with the following clinical markers: maximum WBC and duration of raised WBC, duration of anuria and duration of need for dialysis. None of these outcome measures or prognostic factors, and no extra-renal manifestations of the disease were associated with P1 phenotype.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
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| pubmed:issn |
0141-9854
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
11-4
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:10762298-Acute Kidney Injury,
pubmed-meshheading:10762298-Age Factors,
pubmed-meshheading:10762298-Biological Markers,
pubmed-meshheading:10762298-Child,
pubmed-meshheading:10762298-Child, Preschool,
pubmed-meshheading:10762298-Diarrhea,
pubmed-meshheading:10762298-Escherichia coli Infections,
pubmed-meshheading:10762298-Escherichia coli O157,
pubmed-meshheading:10762298-Female,
pubmed-meshheading:10762298-Hemolytic-Uremic Syndrome,
pubmed-meshheading:10762298-Humans,
pubmed-meshheading:10762298-Hypertension,
pubmed-meshheading:10762298-Infant,
pubmed-meshheading:10762298-Male,
pubmed-meshheading:10762298-P Blood-Group System,
pubmed-meshheading:10762298-Phenotype,
pubmed-meshheading:10762298-Prognosis,
pubmed-meshheading:10762298-Proteinuria,
pubmed-meshheading:10762298-Risk Factors,
pubmed-meshheading:10762298-Scotland,
pubmed-meshheading:10762298-Sex Factors
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| pubmed:year |
2000
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| pubmed:articleTitle |
Haemolytic uraemic syndrome: prognostic factors.
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| pubmed:affiliation |
Royal Hospital for Sick Children, Royal Infirmary, Edinburgh, UK.
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| pubmed:publicationType |
Journal Article
|