Linked Life Data

10760644

Source:http://linkedlifedata.com/resource/pubmed/id/10760644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-5-11
pubmed:abstractText
Recent research suggests that exposure to organochlorines, such as dieldrin that possess estrogenic properties, may increase the risk of breast cancer by promoting growth of malignant cells. Whether this potential also affects malignant cells not eradicated by treatment, and thereby survival, is unknown. To evaluate this blood samples from female participants in the Copenhagen City Heart Study, Denmark, were analyzed for organochlorines. A total of 195 breast cancer cases, who each provided two blood samples that were taken in 1976-78 and 1981-83, respectively, were included in the survival analysis. Dieldrin had a significant adverse effect on overall survival and breast cancer specific survival (RR, 2.78, 95% CI, 1. 38-5.59, P trend < 0.01; RR, 2.61, 95% CI, 0.97-7.01, P trend < 0. 01). This association was strengthened when exposure was assessed as the average serum concentration of the two measurements. These findings suggest that past exposure to estrogenic organochlorines such as dieldrin may not only affect the risk of developing breast cancer but also the survival.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0895-4356
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Organochlorine exposure and breast cancer survival.
pubmed:affiliation
The Center of Preventive Medicine, KAS Glostrup, Denmark and Copenhagen Center for Prospective Population Studies, Frederiksberg C, Denmark. APH@Post8.tele.dle
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't