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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant familial cancer syndrome characterized by tumours of the parathyroids, anterior pituitary gland and endocrine pancreas. Since the cloning of the MEN1 gene (encoding menin) on chromosome 11q13 by Chandrasekharappa et al. in 1997, it has become possible to identify mutations that are responsible. We examined whether MEN1 gene mutations are present in sporadic insulinomas, a rare sporadic tumour that is seen more frequently in patients with the MEN 1 syndrome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2972
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10759881-Adolescent,
pubmed-meshheading:10759881-Adult,
pubmed-meshheading:10759881-Aged,
pubmed-meshheading:10759881-Amino Acid Substitution,
pubmed-meshheading:10759881-Chromosome Mapping,
pubmed-meshheading:10759881-Chromosomes, Human, Pair 11,
pubmed-meshheading:10759881-Exons,
pubmed-meshheading:10759881-Female,
pubmed-meshheading:10759881-Genes, Tumor Suppressor,
pubmed-meshheading:10759881-Genetic Predisposition to Disease,
pubmed-meshheading:10759881-Heterozygote Detection,
pubmed-meshheading:10759881-Homozygote,
pubmed-meshheading:10759881-Humans,
pubmed-meshheading:10759881-Insulinoma,
pubmed-meshheading:10759881-Male,
pubmed-meshheading:10759881-Middle Aged,
pubmed-meshheading:10759881-Multiple Endocrine Neoplasia Type 1,
pubmed-meshheading:10759881-Neoplasm Proteins,
pubmed-meshheading:10759881-Pancreatic Neoplasms,
pubmed-meshheading:10759881-Proto-Oncogene Proteins,
pubmed-meshheading:10759881-Reproducibility of Results
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pubmed:year |
2000
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pubmed:articleTitle |
Lack of MEN1 gene mutations in 27 sporadic insulinomas.
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pubmed:affiliation |
Heinrich-Heine-University, Düsseldorf; Institute for Hormone and Fertility Research at the University of Hamburg, Hamburg, Germany.
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pubmed:publicationType |
Journal Article
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