|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002190,
umls-concept:C0030685,
umls-concept:C0138741,
umls-concept:C0220806,
umls-concept:C0391871,
umls-concept:C0439855,
umls-concept:C0680255,
umls-concept:C0936012,
umls-concept:C1283071,
umls-concept:C1880497,
umls-concept:C1963578,
umls-concept:C1996904
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|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2000-4-21
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|
pubmed:abstractText |
Prostate-specific antigen (PSA), a marker for prostate cancer (CaP), forms a covalent complex with alpha(1)-antichymotrypsin (ACT) in human blood. Structural analysis of the PSA-ACT complex is difficult, and complexation may be a reason for biased immunological assays when compared with the analysis of free PSA. We developed a method to cleave the PSA-ACT complex chemically. The liberated PSA was thus available for analysis as free PSA (F-PSA).
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0009-9147
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
46
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
474-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10759471-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:10759471-Ethanolamine,
pubmed-meshheading:10759471-Humans,
pubmed-meshheading:10759471-Immunoassay,
pubmed-meshheading:10759471-Indicators and Reagents,
pubmed-meshheading:10759471-Male,
pubmed-meshheading:10759471-Mass Spectrometry,
pubmed-meshheading:10759471-Prostate-Specific Antigen,
pubmed-meshheading:10759471-Prostatic Neoplasms,
pubmed-meshheading:10759471-Reference Standards,
pubmed-meshheading:10759471-Tumor Markers, Biological,
pubmed-meshheading:10759471-alpha 1-Antichymotrypsin
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
Analysis of free prostate-specific antigen (PSA) after chemical release from the complex with alpha(1)-antichymotrypsin (PSA-ACT).
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pubmed:affiliation |
Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany.
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pubmed:publicationType |
Journal Article
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