Linked Life Data

10757079

Source:http://linkedlifedata.com/resource/pubmed/id/10757079

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-6-16
pubmed:abstractText
Dendritic cells play an important role in regulating both normal and pathophysiologic immune responses. Complicating the interpretation of dendritic cell function has been the observation that dendritic cells are not only rare, but can demonstrate multiple maturation/differentiation states. Despite these experimental limitations, the accumulating evidence suggests that dendritic cell are a dynamic migratory population that can be recruited into areas of peripheral inflammation. In the peripheral site of inflammation, dendritic cell function appears to involve the processing of antigen and its subsequent presentation to T lymphocytes. Dendritic cells also appear to be capable of transporting antigen to the regional lymph node through the afferent lymphatics. Dendritic cells can be found in the paracortex where they appear to be interacting with T lymphocytes to provide both membrane-bound and soluble activation signals. The central regulatory role of the dendritic cell in immune responses suggests that sarcoidal reactions, and other mononuclear inflammatory processes, are likely to be clinical entities that reflect perturbed dendritic cell function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0258-851X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-12
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Dendritic cells in the pathophysiology of sarcoidal reactions.
pubmed:affiliation
Laboratory of Immunophysiology, Dana-Farber Cancer Institute, Boston, MA, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review