| pubmed-article:10756192 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C1417098 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0205112 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0337076 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0920533 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0012751 | lld:lifeskim |
| pubmed-article:10756192 | lifeskim:mentions | umls-concept:C0332158 | lld:lifeskim |
| pubmed-article:10756192 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10756192 | pubmed:dateCreated | 2000-6-20 | lld:pubmed |
| pubmed-article:10756192 | pubmed:abstractText | The pathways for selective transcriptional repression of methylated DNA templates by the methyl-CpG-binding protein MeCP2 have been investigated using a purified in vitro transcription system that does not assemble chromatin. MeCP2 selectively inhibits transcription complex assembly on methylated DNA but does not destabilize a pre-assembled transcription complex. MeCP2 functions to repress transcription at a distance of >500 bp from the transcription start site. The transcription repression domain (TRD) of MeCP2 will repress transcription in vitro when fused to a heterologous Gal4 DNA-binding domain. The TRD associates with TFIIB. Exogenous TFIIB does not relieve transcriptional repression established by either intact MeCP2 or a Gal4-TRD fusion protein under these in vitro conditions, nor does the addition of histone deacetylase inhibitors. We find that the transcriptional repression established by both MeCP2 and the Gal4-TRD fusion protein in vitro also correlates with selective assembly of large nucleoprotein complexes. The formation of such complexes reflects a local concentration of DNA-bound transcriptional repressor that may stabilize a state of repression even in the presence of exogenous transcriptional machinery. | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10756192 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10756192 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10756192 | pubmed:month | May | lld:pubmed |
| pubmed-article:10756192 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:10756192 | pubmed:author | pubmed-author:WolffeA PAP | lld:pubmed |
| pubmed-article:10756192 | pubmed:author | pubmed-author:KaludovN KNK | lld:pubmed |
| pubmed-article:10756192 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:10756192 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10756192 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:10756192 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10756192 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10756192 | pubmed:pagination | 1921-8 | lld:pubmed |
| pubmed-article:10756192 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:meshHeading | pubmed-meshheading:10756192... | lld:pubmed |
| pubmed-article:10756192 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10756192 | pubmed:articleTitle | MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery. | lld:pubmed |
| pubmed-article:10756192 | pubmed:affiliation | Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, USA. | lld:pubmed |
| pubmed-article:10756192 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:2959 | entrezgene:pubmed | pubmed-article:10756192 | lld:entrezgene |
| entrez-gene:4204 | entrezgene:pubmed | pubmed-article:10756192 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:10756192 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10756192 | lld:pubmed |
