Linked Life Data

10754500

Source:http://linkedlifedata.com/resource/pubmed/id/10754500

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-4-27
pubmed:abstractText
Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of the carcinomas. There was a significant association of staining for S100A4 with tumours fixed to the chest wall, staining for c-erbB-2, c-erbB-3, pS2, cathepsin D and, inversely, at borderline levels with staining for estrogen receptor. Using Wilcoxon statistics in univariate analyses, staining for S100A4, nodal status, tumour class, histological grade and staining for c-erbB-2, p53 were associated negatively and staining for estrogen receptor, progesterone receptor were associated positively with patient survival times. The survival times of patients with S100A4-negative carcinomas with or without one of the other tumour variables showed no significant differences, whilst those of patients with S100A4-positive carcinomas showed significant differences in a negative or a positive way. Multivariate regression analysis for 137 patients showed that staining for S100A4 is most highly correlated with patient deaths, but involved lymph nodes, fixed tumours, high histological grade and staining for progesterone receptor were also significant independent prognostic variables. Our results suggest that in this set of patients, the tumour variable most tightly correlated with patient death is S100A4.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
198-208
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10754500-Adult, pubmed-meshheading:10754500-Aged, pubmed-meshheading:10754500-Aged, 80 and over, pubmed-meshheading:10754500-Blotting, Western, pubmed-meshheading:10754500-Breast, pubmed-meshheading:10754500-Breast Neoplasms, pubmed-meshheading:10754500-Female, pubmed-meshheading:10754500-Humans, pubmed-meshheading:10754500-Immunohistochemistry, pubmed-meshheading:10754500-Lymphatic Metastasis, pubmed-meshheading:10754500-Middle Aged, pubmed-meshheading:10754500-Neoplasm Staging, pubmed-meshheading:10754500-Predictive Value of Tests, pubmed-meshheading:10754500-Prognosis, pubmed-meshheading:10754500-Receptor, erbB-2, pubmed-meshheading:10754500-Receptors, Estrogen, pubmed-meshheading:10754500-Receptors, Progesterone, pubmed-meshheading:10754500-Risk Factors, pubmed-meshheading:10754500-S100 Proteins, pubmed-meshheading:10754500-Survival Analysis, pubmed-meshheading:10754500-Tumor Markers, Biological, pubmed-meshheading:10754500-Tumor Suppressor Protein p53
pubmed:year
2000
pubmed:articleTitle
Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer.
pubmed:affiliation
School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't