Source:http://linkedlifedata.com/resource/pubmed/id/10753634
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-5-8
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pubmed:abstractText |
Borato-1,2-diaminocyclohexane platinum (II) (BDP) was synthesized and compared to cisplatin (cisPt) as a potential anti-tumor drug. BDP and cisPt (0.2-20 microM) dose-dependently inhibited DNA synthesis in L1210 murine leukemia cells, DU-145 prostate cancer cells, A549 lung carcinoma cells, and MCF-7 breast cancer cells, as judged by measuring [(3)H]-thymidine incorporation. BDP and cisPt induced killing of L1210 murine cells by 97 and 78%, respectively. The LD(50) was 35 and 14 mg/kg for BDP and cisPt, respectively. Interestingly, while cisPt (at optimal dose) induced a 100% increase in life span (ILS) of BDF1 mice bearing L1210 tumor cells, BDP (at optimal dose) induced a 200% increase in ILS in the same tumor model. In conclusion, BDP is a novel platinum derivative compound that appears more effective in increasing the ILS than cisplatin against the leukemia tumor mouse model.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10753634-Animals,
pubmed-meshheading:10753634-Antineoplastic Agents,
pubmed-meshheading:10753634-Boron Compounds,
pubmed-meshheading:10753634-DNA Replication,
pubmed-meshheading:10753634-Humans,
pubmed-meshheading:10753634-Lethal Dose 50,
pubmed-meshheading:10753634-Mice,
pubmed-meshheading:10753634-Organoplatinum Compounds,
pubmed-meshheading:10753634-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Borato-1,2-diaminocyclohexane platinum (II), a novel anti-tumor drug.
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pubmed:affiliation |
Mary Kay Ash Institute for Cancer Research, St. Paul Medical Center, Dallas, Texas 75235, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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