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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5463
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pubmed:dateCreated |
2000-4-13
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pubmed:abstractText |
Basement membranes can help determine pathways of migrating axons. Although members of the nidogen (entactin) protein family are structural components of basement membranes, we find that nidogen is not required for basement membrane assembly in the nematode Caenorhabditis elegans. Nidogen is localized to body wall basement membranes and is required to direct longitudinal nerves dorsoventrally and to direct axons at the midlines. By examining migration of a single axon in vivo, we show that nidogen is required for the axon to switch from circumferential to longitudinal migration. Specialized basement membranes may thus regulate nerve position.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-4
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:10753123-Amino Acid Motifs,
pubmed-meshheading:10753123-Animals,
pubmed-meshheading:10753123-Animals, Genetically Modified,
pubmed-meshheading:10753123-Axons,
pubmed-meshheading:10753123-Basement Membrane,
pubmed-meshheading:10753123-Body Patterning,
pubmed-meshheading:10753123-Caenorhabditis elegans,
pubmed-meshheading:10753123-Caenorhabditis elegans Proteins,
pubmed-meshheading:10753123-Cell Adhesion Molecules,
pubmed-meshheading:10753123-Cell Movement,
pubmed-meshheading:10753123-Cloning, Molecular,
pubmed-meshheading:10753123-Gene Expression,
pubmed-meshheading:10753123-Genes, Helminth,
pubmed-meshheading:10753123-In Situ Hybridization,
pubmed-meshheading:10753123-Intestines,
pubmed-meshheading:10753123-Membrane Glycoproteins,
pubmed-meshheading:10753123-Motor Neurons,
pubmed-meshheading:10753123-Muscles,
pubmed-meshheading:10753123-Nervous System,
pubmed-meshheading:10753123-Neurons,
pubmed-meshheading:10753123-Phenotype,
pubmed-meshheading:10753123-Protein Structure, Tertiary,
pubmed-meshheading:10753123-Receptors, Cell Surface,
pubmed-meshheading:10753123-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
Positioning of longitudinal nerves in C. elegans by nidogen.
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pubmed:affiliation |
Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635, USA.
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pubmed:publicationType |
Journal Article
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