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rdf:type |
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lifeskim:mentions |
umls-concept:C0035553,
umls-concept:C0205099,
umls-concept:C0439855,
umls-concept:C0678594,
umls-concept:C1514562,
umls-concept:C1552144,
umls-concept:C1706853,
umls-concept:C1879748,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
5463
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pubmed:dateCreated |
2000-4-13
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pubmed:databankReference |
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pubmed:abstractText |
The crystal structure of a 70-kilodalton ribonucleoprotein complex from the central domain of the Thermus thermophilus 30S ribosomal subunit was solved at 2.6 angstrom resolution. The complex consists of a 104-nucleotide RNA fragment composed of two three-helix junctions that lie at the end of a central helix, and the ribosomal proteins S15, S6, and S18. S15 binds the ribosomal RNA early in the assembly of the 30S ribosomal subunit, stabilizing a conformational reorganization of the two three-helix junctions that creates the RNA fold necessary for subsequent binding of S6 and S18. The structure of the complex demonstrates the central role of S15-induced reorganization of central domain RNA for the subsequent steps of ribosome assembly.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-13
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10753109-Amino Acid Sequence,
pubmed-meshheading:10753109-Bacterial Proteins,
pubmed-meshheading:10753109-Base Pairing,
pubmed-meshheading:10753109-Base Sequence,
pubmed-meshheading:10753109-Binding Sites,
pubmed-meshheading:10753109-Crystallography, X-Ray,
pubmed-meshheading:10753109-Models, Molecular,
pubmed-meshheading:10753109-Molecular Sequence Data,
pubmed-meshheading:10753109-Nucleic Acid Conformation,
pubmed-meshheading:10753109-Protein Binding,
pubmed-meshheading:10753109-Protein Conformation,
pubmed-meshheading:10753109-Protein Structure, Secondary,
pubmed-meshheading:10753109-Protein Structure, Tertiary,
pubmed-meshheading:10753109-RNA, Bacterial,
pubmed-meshheading:10753109-RNA, Ribosomal,
pubmed-meshheading:10753109-Ribonucleoproteins,
pubmed-meshheading:10753109-Ribosomal Protein S6,
pubmed-meshheading:10753109-Ribosomal Proteins,
pubmed-meshheading:10753109-Ribosomes,
pubmed-meshheading:10753109-Thermus thermophilus
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pubmed:year |
2000
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pubmed:articleTitle |
Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain.
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pubmed:affiliation |
Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. dave@scripps.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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