Source:http://linkedlifedata.com/resource/pubmed/id/10751392
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
27
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| pubmed:dateCreated |
2000-8-16
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| pubmed:abstractText |
Both in vitro and in vivo studies of scavenger receptor class B type I (SR-BI) have implicated it as a likely participant in the metabolism of HDL cholesterol. To investigate the effect of SR-BI on atherogenesis, we examined two lines of SR-BI transgenic mice with high (10-fold increases) and low (2-fold increases) SR-BI expression in an inbred mouse background hemizygous for a human apolipoprotein (apo) B transgene. Unlike non-HDL cholesterol levels that minimally differed in the various groups of animals, HDL cholesterol levels were inversely related to SR-BI expression. Mice with the low expression SR-BI transgene had a 50% reduction in HDL cholesterol, whereas the high expression SR-BI transgene was associated with 2-fold decreases in HDL cholesterol as well as dramatic alterations in HDL composition and size including the near absence of alpha-migrating particles as determined by two-dimensional electrophoresis. The low expression SR-BI/apo B transgenics had more than a 2-fold decrease in the development of diet-induced fatty streak lesions compared with the apo B transgenics (4448 +/- 1908 micrometer(2)/aorta to 10133 +/- 4035 micrometer (2)/aorta; p < 0.001), whereas the high expression SR-BI/apo B transgenics had an atherogenic response similar to that of the apo B transgenics (14692 +/- 7238 micrometer(2)/aorta) but 3-fold greater than the low SR-BI/apo B mice (p < 0.001). The prominent anti-atherogenic effect of moderate SR-BI expression provides in vivo support for the hypothesis that HDL functions to inhibit atherogenesis through its interactions with SR-BI in facilitating reverse cholesterol transport. The failure of the high SR-BI/apo B transgenics to have similar or even greater reductions in atherogenesis suggests that the changes resulting from extremely high SR-BI expression including dramatic changes in lipoproteins may have both pro- and anti-atherogenic consequences, illustrating the complexity of the relationship between SR-BI and atherogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD36,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/SCARB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0021-9258
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
7
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| pubmed:volume |
275
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
20368-73
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10751392-Animals,
pubmed-meshheading:10751392-Antigens, CD36,
pubmed-meshheading:10751392-Aorta,
pubmed-meshheading:10751392-Apolipoproteins B,
pubmed-meshheading:10751392-Arteriosclerosis,
pubmed-meshheading:10751392-Cholesterol, HDL,
pubmed-meshheading:10751392-Diet, Atherogenic,
pubmed-meshheading:10751392-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:10751392-Female,
pubmed-meshheading:10751392-Gene Expression Regulation,
pubmed-meshheading:10751392-Histocytochemistry,
pubmed-meshheading:10751392-Humans,
pubmed-meshheading:10751392-Lipids,
pubmed-meshheading:10751392-Lipoproteins, HDL,
pubmed-meshheading:10751392-Liver,
pubmed-meshheading:10751392-Membrane Proteins,
pubmed-meshheading:10751392-Mice,
pubmed-meshheading:10751392-Mice, Transgenic,
pubmed-meshheading:10751392-Myocardium,
pubmed-meshheading:10751392-Receptors, Immunologic,
pubmed-meshheading:10751392-Receptors, LDL,
pubmed-meshheading:10751392-Receptors, Lipoprotein,
pubmed-meshheading:10751392-Receptors, Scavenger,
pubmed-meshheading:10751392-Ribonucleases,
pubmed-meshheading:10751392-Scavenger Receptors, Class B
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| pubmed:year |
2000
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| pubmed:articleTitle |
Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics.
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| pubmed:affiliation |
Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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