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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-5-16
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pubmed:abstractText |
Endothelins can act as polyfunctional cytokines. It is therefore possible that endothelins could play an active role in gut inflammation. Elevated levels of endothelin-1 have been reported in ulcerative colitis and Crohn's disease. The aim of this study was to establish the therapeutic effect of a 'new' endothelin receptor antagonist Ro 48-5695 in an animal model of inflammatory bowel disease. This study compares the effect of Ro 48-5695 on colonic damage induced by two haptens: trinitrobenzenesulphonic (TNBS) or dinitrobenzenesulphonic acid (DNBS).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0954-691X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-65
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pubmed:dateRevised |
2009-10-16
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pubmed:meshHeading |
pubmed-meshheading:10750644-Animals,
pubmed-meshheading:10750644-Benzenesulfonates,
pubmed-meshheading:10750644-Colitis, Ulcerative,
pubmed-meshheading:10750644-Disease Models, Animal,
pubmed-meshheading:10750644-Endothelin-1,
pubmed-meshheading:10750644-Inflammatory Bowel Diseases,
pubmed-meshheading:10750644-Male,
pubmed-meshheading:10750644-Peroxidase,
pubmed-meshheading:10750644-Rats,
pubmed-meshheading:10750644-Rats, Sprague-Dawley,
pubmed-meshheading:10750644-Receptors, Endothelin,
pubmed-meshheading:10750644-Sulfonamides,
pubmed-meshheading:10750644-Trinitrobenzenesulfonic Acid
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pubmed:year |
2000
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pubmed:articleTitle |
Therapeutic effects of the endothelin receptor antagonist Ro 48-5695 in the TNBS/DNBS rat model of colitis.
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pubmed:affiliation |
Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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