Source:http://linkedlifedata.com/resource/pubmed/id/10750638
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-5-24
|
| pubmed:abstractText |
Carnitine derivatives may have beneficial effects on cardiac and nerve function in patients with diabetes. The aim of this study was to investigate the effect of acetyl-L-carnitine (ALC) on myocardial sympathetic nervous function as measured with 123I-meta-iodobenzyl guanidine (MIBG) and single-photon emission tomography (SPET) in 19 patients with diabetes (placebo group, n = 6; ALC group, n = 13) at the beginning and at the end of a 1-year randomized, placebo-controlled, double-blind trial. The coefficient of variation for the MIBG analysis was 4%. In patients who were given a placebo, global myocardial MIBG uptake deteriorated during the study (MIBG uptake 1-year follow-up/baseline, 0.86 +/- 0.05, mean +/- standard error of mean), whereas in patients treated with ALC, MIBG uptake did not change significantly (1-year follow-up/baseline, 1.07 +/- 0.08; p = 0.03 between the groups). On the basis of these preliminary data, we conclude that long-term treatment with ALC may be of potential value in preventing the progressive loss of myocardial sympathetic nervous function in patients with diabetes. MIBG-SPET is a sensitive and thus valuable method in assessing the development of myocardial sympathetic nervous dysfunction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0959-9851
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10750638-3-Iodobenzylguanidine,
pubmed-meshheading:10750638-Acetylcarnitine,
pubmed-meshheading:10750638-Adolescent,
pubmed-meshheading:10750638-Child,
pubmed-meshheading:10750638-Diabetes Mellitus,
pubmed-meshheading:10750638-Double-Blind Method,
pubmed-meshheading:10750638-Female,
pubmed-meshheading:10750638-Heart,
pubmed-meshheading:10750638-Heart Conduction System,
pubmed-meshheading:10750638-Humans,
pubmed-meshheading:10750638-Iodine Radioisotopes,
pubmed-meshheading:10750638-Male,
pubmed-meshheading:10750638-Middle Aged,
pubmed-meshheading:10750638-Myocardium,
pubmed-meshheading:10750638-Prospective Studies,
pubmed-meshheading:10750638-Radiopharmaceuticals,
pubmed-meshheading:10750638-Sympathetic Nervous System,
pubmed-meshheading:10750638-Time Factors,
pubmed-meshheading:10750638-Tomography, Emission-Computed, Single-Photon
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes.
|
| pubmed:affiliation |
Department of Clinical Nutrition and Medicine, University of Kuopio, and Kuopio University Hospital, Finland. anu.turpeinen@kuh.fi
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|