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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2000-5-12
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pubmed:abstractText |
Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However, somatic (acquired) mutations in BRCA1 have not been reported, despite frequent loss of heterozygosity (LOH or loss of one copy of the gene) at the BRCA1 locus and loss of BRCA1 protein in tumors. To address whether BRCA1 may be inactivated by pathways other than mutations in sporadic tumors, we analyzed the role of hypermethylation of the gene's promoter region.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8874
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pubmed:author |
pubmed-author:BaylinS BSB,
pubmed-author:BonillaFF,
pubmed-author:BussagliaEE,
pubmed-author:DominguezGG,
pubmed-author:EstellerMM,
pubmed-author:GabrielsonEE,
pubmed-author:HarkesI CIC,
pubmed-author:HermanJ GJG,
pubmed-author:LermaEE,
pubmed-author:Matias-GuiuXX,
pubmed-author:PratJJ,
pubmed-author:RepaskyE AEA,
pubmed-author:SchutteMM,
pubmed-author:SilvaJ MJM
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
564-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10749912-Breast Neoplasms,
pubmed-meshheading:10749912-Carcinoma, Ductal, Breast,
pubmed-meshheading:10749912-Female,
pubmed-meshheading:10749912-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10749912-Genes, BRCA1,
pubmed-meshheading:10749912-Humans,
pubmed-meshheading:10749912-Loss of Heterozygosity,
pubmed-meshheading:10749912-Methylation,
pubmed-meshheading:10749912-Ovarian Neoplasms,
pubmed-meshheading:10749912-Promoter Regions, Genetic,
pubmed-meshheading:10749912-RNA,
pubmed-meshheading:10749912-RNA, Neoplasm,
pubmed-meshheading:10749912-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10749912-Transplantation, Heterologous,
pubmed-meshheading:10749912-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
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pubmed:affiliation |
The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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