Linked Life Data

10749783

Source:http://linkedlifedata.com/resource/pubmed/id/10749783

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-5-4
pubmed:abstractText
The role of the central nervous system in the host response to infection and inflammation and modulation of these responses by the hypothalamic-pituitary-adrenal system are well established. In animals, activation of host defense mechanisms increases non-rapid eye movement (NREM) sleep amount and intensity, which, in turn, are thought to support host defense, or the body's ability to defend itself against challenges to its immune system. In humans, the evidence is conflicting. Therefore, we investigated the effects of three placebo-controlled doses of endotoxin on host response, including nocturnal sleep in healthy volunteers. Administered before nocturnal sleep onset, endotoxin dose dependently increased rectal temperature, heart rate, and the plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-1 receptor antagonist, IL-6, and cortisol. The lowest dose reliably increased circulating levels of cytokines and soluble cytokine receptors, but it did not affect rectal temperature, heart rate, or cortisol. This subtle host defense activation increased deep NREM sleep amount, often referred to as slow-wave sleep (stages 3 and 4), and intensity (delta power). Conversely, the highest dose of endotoxin disrupted sleep. Whereas it is well established that the endocrine and thermoregulatory systems are very sensitive to endotoxin, this study shows that human sleep-wake behavior is even more sensitive to activation of host defense mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
278
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R947-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10749783-Adult, pubmed-meshheading:10749783-Body Temperature Regulation, pubmed-meshheading:10749783-Dose-Response Relationship, Drug, pubmed-meshheading:10749783-Electroencephalography, pubmed-meshheading:10749783-Electromyography, pubmed-meshheading:10749783-Electrooculography, pubmed-meshheading:10749783-Fever, pubmed-meshheading:10749783-Heart Rate, pubmed-meshheading:10749783-Humans, pubmed-meshheading:10749783-Hydrocortisone, pubmed-meshheading:10749783-Hypothalamo-Hypophyseal System, pubmed-meshheading:10749783-Injections, Intravenous, pubmed-meshheading:10749783-Interleukin 1 Receptor Antagonist Protein, pubmed-meshheading:10749783-Interleukin-6, pubmed-meshheading:10749783-Leukocyte Count, pubmed-meshheading:10749783-Lipopolysaccharides, pubmed-meshheading:10749783-Male, pubmed-meshheading:10749783-Neuroimmunomodulation, pubmed-meshheading:10749783-Pituitary-Adrenal System, pubmed-meshheading:10749783-Sialoglycoproteins, pubmed-meshheading:10749783-Single-Blind Method, pubmed-meshheading:10749783-Sleep Stages, pubmed-meshheading:10749783-Tumor Necrosis Factor-alpha
pubmed:year
2000
pubmed:articleTitle
Dose-dependent effects of endotoxin on human sleep.
pubmed:affiliation
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany. mullingt@caregroup.harvard.edu
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't