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pubmed-article:10748422pubmed:abstractTextOptically enhanced NMR with (129)Xe and (3)He is emerging as a novel and promising technique for medical imaging of lungs and other tissues. Here it is shown that hyperpolarized (129)Xe NMR provides a powerful means of measuring blood oxygenation quantitatively and noninvasively. The interaction of xenon with hemoglobin is responsible for an oxygen-dependent NMR shift of (129)Xe in red blood cells, in sharp contrast to the current model of xenon-hemoglobin binding. This effect could be exploited in brain functional studies, and in the assessment of conditions and diseases affected by blood oxygenation.lld:pubmed
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pubmed-article:10748422pubmed:articleTitleHyperpolarized 129Xe NMR as a probe for blood oxygenation.lld:pubmed
pubmed-article:10748422pubmed:affiliationCRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research, The Royal Marsden NHS Trust, Sutton, Surrey, UK.lld:pubmed
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