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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2000-7-20
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pubmed:abstractText |
Proliferation of vascular smooth muscle cells (VSMC) is characteristic of restenosis following balloon angioplasty. We show here that a low concentration of a novel iron chelator, desferri-exochelin 772SM, reversibly arrests the growth of human VSMC in vitro, specifically in G(0)/G(1) and S phases. The lipophilic desferri-exochelin is effective more rapidly and at a 10-fold lower concentration than the nonlipophilic iron chelator deferoxamine. Treatment of growth-synchronized VSMC with the desferri-exochelin results in down-regulation of cyclin E/ Cdk2 and cyclin A/Cdk2 activity but does not affect the cyclin D/Cdk4/retinoblastoma phosphorylation pathway. Both DNA replication and RNA transcription are inhibited in exochelin-treated cells, but protein synthesis is not. The ability of desferri-exochelin 772SM to reversibly block the growth of VSMC in vitro with no apparent cytotoxicity suggests that the exochelin may be useful as a therapeutic agent to limit restenosis in injured vessels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/CDK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Deferoxamine,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Ferric Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Iron Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/ferriexochelin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
275
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17821-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10748174-Aorta,
pubmed-meshheading:10748174-CDC2-CDC28 Kinases,
pubmed-meshheading:10748174-Cell Cycle,
pubmed-meshheading:10748174-Cell Division,
pubmed-meshheading:10748174-Cells, Cultured,
pubmed-meshheading:10748174-Cyclin E,
pubmed-meshheading:10748174-Cyclin-Dependent Kinase 2,
pubmed-meshheading:10748174-Cyclin-Dependent Kinases,
pubmed-meshheading:10748174-Deferoxamine,
pubmed-meshheading:10748174-Dose-Response Relationship, Drug,
pubmed-meshheading:10748174-Epidermal Growth Factor,
pubmed-meshheading:10748174-Ferric Compounds,
pubmed-meshheading:10748174-Humans,
pubmed-meshheading:10748174-Iliac Artery,
pubmed-meshheading:10748174-Iron Chelating Agents,
pubmed-meshheading:10748174-Kinetics,
pubmed-meshheading:10748174-Muscle, Smooth, Vascular,
pubmed-meshheading:10748174-Mycobacterium tuberculosis,
pubmed-meshheading:10748174-Peptides, Cyclic,
pubmed-meshheading:10748174-Phosphorylation,
pubmed-meshheading:10748174-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10748174-Retinoblastoma Protein,
pubmed-meshheading:10748174-Saphenous Vein
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pubmed:year |
2000
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pubmed:articleTitle |
An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro.
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pubmed:affiliation |
Division of Cardiology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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