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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
28
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pubmed:dateCreated |
2000-8-16
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pubmed:abstractText |
PTEN/MMAC is a phosphatase that is mutated in multiple human tumors. PTEN/MMAC dephosphorylates 3-phosphorylated phosphatidylinositol phosphates that activate AKT/protein kinase B (PKB) kinase activity. AKT/PKB is implicated in the inhibition of apoptosis, and cell lines and tumors with mutated PTEN/MMAC show increased AKT/PKB kinase activity and resistance to apoptosis. PTEN/MMAC contains a PDZ domain-binding site, and we show here that the phosphatase binds to a PDZ domain of membrane-associated guanylate kinase with inverted orientation (MAGI) 3, a novel inverted membrane-associated guanylate kinase that localizes to epithelial cell tight junctions. Importantly, MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/PKB. These data suggest that MAGI3 allows for the juxtaposition of PTEN/MMAC to phospholipid signaling pathways involved with cell survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
275
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21477-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10748157-Amino Acid Sequence,
pubmed-meshheading:10748157-Animals,
pubmed-meshheading:10748157-Binding Sites,
pubmed-meshheading:10748157-Cell Line,
pubmed-meshheading:10748157-Conserved Sequence,
pubmed-meshheading:10748157-Epithelial Cells,
pubmed-meshheading:10748157-Female,
pubmed-meshheading:10748157-Genes, Suppressor,
pubmed-meshheading:10748157-Guanylate Kinase,
pubmed-meshheading:10748157-Humans,
pubmed-meshheading:10748157-Male,
pubmed-meshheading:10748157-Membrane Proteins,
pubmed-meshheading:10748157-Molecular Sequence Data,
pubmed-meshheading:10748157-Nucleoside-Phosphate Kinase,
pubmed-meshheading:10748157-Organ Specificity,
pubmed-meshheading:10748157-PTEN Phosphohydrolase,
pubmed-meshheading:10748157-Phosphoric Monoester Hydrolases,
pubmed-meshheading:10748157-Recombinant Proteins,
pubmed-meshheading:10748157-Saccharomyces cerevisiae,
pubmed-meshheading:10748157-Sequence Alignment,
pubmed-meshheading:10748157-Sequence Homology, Amino Acid,
pubmed-meshheading:10748157-Tight Junctions,
pubmed-meshheading:10748157-Tumor Cells, Cultured,
pubmed-meshheading:10748157-Tumor Suppressor Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.
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pubmed:affiliation |
Departments of Molecular Oncology and Molecular Biology, Genentech, Inc., South San Francisco, California 94080, USA.
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pubmed:publicationType |
Journal Article
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