Linked Life Data

10746799

Source:http://linkedlifedata.com/resource/pubmed/id/10746799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl
pubmed:dateCreated
2000-5-18
pubmed:abstractText
Normochromic normocytic anemia regularly develops in chronic renal failure when the glomerular filtration rate drops below 20-30 ml/min. The reasons include: 1) a moderately reduced red cell life span, 2) blood loss, and 3) an inadequate increase in erythropoiesis relative to the fall in hemoglobin (Hb). The life-span of red blood cells may be shortened by their reduced resistance to mechanical, osmotic or oxidative stress, as well as by extracorpuscular factors. Blood loss results from dialysis, diagnostic sampling and, in particular, occult gastrointestinal bleeding. The predominant cause of inadequate erythropoiesis is a failure to increase erythropoietin (EPO) production in response to the developing anemia. Experience with recombinant EPO has shown that relative EPO deficiency is the key cause of the anemia and that the response of hematopoietic progenitor cells is not usually diminished in renal failure. However, reduced iron availability, inadequate dialysis, infection and hyperparathyroidism can all impair the efficacy of EPO. Therapeutic use of EPO has also shown clearly for the first time that anemia is responsible for a significant proportion of morbidity in patients with chronic renal failure and probably also contributes to increased mortality through its cardiovascular complications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0301-0430
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S2-8
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Pathophysiology of renal anemia.
pubmed:affiliation
Medical Clinic, Department of Nephrology and Intensive Care Medicine, Humboldt University Berlin, Germany.
pubmed:publicationType
Journal Article, Review