Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-6-19
pubmed:databankReference
pubmed:abstractText
In mammals, the classical B7 molecules expressed on antigen-presenting cells, B7-1 (CD80) and B7-2 (CD86), bind the structurally related glycoproteins CD28 and CTLA-4 (CD152), generating costimulatory signals that regulate the activation state of T cells. A recently identified human CD28-like protein, ICOS, also induces costimulatory signals in T cells when crosslinked with antibodies, but it is unclear whether ICOS is part of a B7-mediated regulatory pathway of previously unsuspected complexity, or whether it functions independently and in parallel. Here, we report that, rather than binding B7-1 or B7-2, ICOS binds a new B7-related molecule of previously unknown function that we call LICOS (for ligand of ICOS). At 37 degrees C, LICOS binds only to ICOS but, at lower, non-physiological temperatures, it also binds weakly to CD28 and CTLA-4. Sequence comparisons suggest that LICOS is the homologue of a molecule expressed by avian macrophages and of a murine protein whose expression is induced in non-lymphoid organs by tumour necrosis factor alpha (TNFalpha). Our results define the components of a distinct and novel costimulatory pathway and raise the possibility that LICOS, rather than B7-1 or B7-2, is the contemporary homologue of a primordial vertebrate costimulatory ligand.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation..., http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary, http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human, http://linkedlifedata.com/resource/pubmed/chemical/ICOSLG protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Icos protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Icosl protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator..., http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator..., http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0960-9822
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10744980-Amino Acid Sequence, pubmed-meshheading:10744980-Animals, pubmed-meshheading:10744980-Antigens, CD, pubmed-meshheading:10744980-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:10744980-Base Sequence, pubmed-meshheading:10744980-Cell Line, Transformed, pubmed-meshheading:10744980-DNA, Complementary, pubmed-meshheading:10744980-Humans, pubmed-meshheading:10744980-Inducible T-Cell Co-Stimulator Ligand, pubmed-meshheading:10744980-Inducible T-Cell Co-Stimulator Protein, pubmed-meshheading:10744980-Ligands, pubmed-meshheading:10744980-Membrane Glycoproteins, pubmed-meshheading:10744980-Mice, pubmed-meshheading:10744980-Molecular Sequence Data, pubmed-meshheading:10744980-Proteins, pubmed-meshheading:10744980-Receptors, Antigen, T-Cell, pubmed-meshheading:10744980-Sequence Homology, Amino Acid, pubmed-meshheading:10744980-Surface Plasmon Resonance
pubmed:year
2000
pubmed:articleTitle
LICOS, a primordial costimulatory ligand?
pubmed:affiliation
Sir William Dunn School of Pathology, The University of Oxford, Oxford, OX1 3RE, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't