Source:http://linkedlifedata.com/resource/pubmed/id/10744348
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2000-6-21
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| pubmed:abstractText |
1. We tested the hypothesis that the transition to pacing-induced failure in hypertrophic hearts would result in reduced functional and metabolic responses to beta-adrenoceptor stimulation. 2. Isoproterenol (ISO; 0.1 microg/kg per min) was infused into a coronary artery in five anaesthetized open-chest control, five aortic stenosis-induced left ventricular hypertrophy (LVH) and five LVH pacing-induced failure dogs. 3. In both control and LVH dogs, but not in failure dogs, ISO significantly increased local regional work (1,923+/-665 vs 2,656+/-715, 1,185+/-286 vs 1,906+/-562 and 835+/-106 vs 849+/-216g.mm/min, respectively), force (11.1+/-1.4 vs 16.9+/-2.6, 8.6+/-1.5 vs 13.7+/-2.3 and 12.2+/-1.1 vs 11.0+/-1.8g, respectively) and myocardial O2 consumption (7.3+/-2.0 vs 10.0+/-1.5, 8.2+/-1.6 vs 11.6+/-2.6 and 4.4+/-1.5 vs 5.5+/-1.8 mL O2/min per 100 g, respectively). 4. Isoproterenol also significantly increased cAMP in control and LVH dogs (474+/-67 vs 600+/-91 and 473+/-34 vs 619+/-53 pmol/g, respectively). In heart failure, cAMP was significantly lower and there was no significant increase in cAMP in response to ISO (245+/-43 vs 314+/-40pmol/g, respectively). 5. We conclude that there were no significant myocardial functional, O2 consumption or cAMP responses to ISO after the transition from hypertrophy to cardiac failure.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0305-1870
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
202-7
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10744348-Adrenergic beta-Agonists,
pubmed-meshheading:10744348-Animals,
pubmed-meshheading:10744348-Aortic Valve Stenosis,
pubmed-meshheading:10744348-Blood Pressure,
pubmed-meshheading:10744348-Body Weight,
pubmed-meshheading:10744348-Cardiac Pacing, Artificial,
pubmed-meshheading:10744348-Coronary Circulation,
pubmed-meshheading:10744348-Cyclic AMP,
pubmed-meshheading:10744348-Dogs,
pubmed-meshheading:10744348-Heart Failure,
pubmed-meshheading:10744348-Hypertrophy, Left Ventricular,
pubmed-meshheading:10744348-Isoproterenol,
pubmed-meshheading:10744348-Myocardial Contraction,
pubmed-meshheading:10744348-Myocardium,
pubmed-meshheading:10744348-Organ Size,
pubmed-meshheading:10744348-Oxygen Consumption
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Effects of beta-adrenoceptor stimulation on pacing-induced failure of dog hypertrophic hearts.
|
| pubmed:affiliation |
Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903-0019, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|