Source:http://linkedlifedata.com/resource/pubmed/id/10743946
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2000-6-26
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pubmed:abstractText |
Recent evidence is consistent with neurotensin (NT)(8-13) adopting a Type I beta-turn conformation while binding the NT receptor, which would place the cationic side-chains of Arg(8) and Arg(9) in close proximity. This was the basis for the design, synthesis and analysis of truncated NT(9-13) analogues 1-5 with dicationic position 9 side-chains to emulate the functions of the 8 and 9 side-chains of NT(8-13).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
453-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10743946-Animals,
pubmed-meshheading:10743946-CHO Cells,
pubmed-meshheading:10743946-Chromatography, High Pressure Liquid,
pubmed-meshheading:10743946-Cricetinae,
pubmed-meshheading:10743946-Humans,
pubmed-meshheading:10743946-Molecular Weight,
pubmed-meshheading:10743946-Neurotensin,
pubmed-meshheading:10743946-Peptide Fragments,
pubmed-meshheading:10743946-Receptors, Neurotensin,
pubmed-meshheading:10743946-Structure-Activity Relationship
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pubmed:year |
2000
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pubmed:articleTitle |
Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinities.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425-2303, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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