rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2000-6-26
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pubmed:abstractText |
SAR studies which focused upon the C-6 position of a recently described series of quinolone gonadotropin releasing hormone antagonists are reported. Synthetic access to diverse quinolone-6-carboxamides was achieved via the palladium-catalyzed amino-carbonylation reactions of iodide 4 with various amines. Amides related to 9y were especially potent, functional antagonists of rat and human GnRH receptors.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChengKK,
pubmed-author:DeVitaR JRJ,
pubmed-author:FisherM HMH,
pubmed-author:GouletM TMT,
pubmed-author:HuangS XSX,
pubmed-author:LoJ LJL,
pubmed-author:ReiCC,
pubmed-author:SmithR GRG,
pubmed-author:ToupenceR BRB,
pubmed-author:UjjainwallaFF,
pubmed-author:WalshT FTF,
pubmed-author:WyvrattM JMJJr,
pubmed-author:YangY TYT,
pubmed-author:YoungJ RJR,
pubmed-author:YudkovitzJ BJB
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pubmed:issnType |
Print
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pubmed:day |
6
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
443-7
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10743944-Amides,
pubmed-meshheading:10743944-Animals,
pubmed-meshheading:10743944-CHO Cells,
pubmed-meshheading:10743944-Cricetinae,
pubmed-meshheading:10743944-Humans,
pubmed-meshheading:10743944-Luteinizing Hormone,
pubmed-meshheading:10743944-Phosphatidylinositols,
pubmed-meshheading:10743944-Quinolones,
pubmed-meshheading:10743944-Rats,
pubmed-meshheading:10743944-Receptors, LHRH,
pubmed-meshheading:10743944-Stereoisomerism,
pubmed-meshheading:10743944-Structure-Activity Relationship
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pubmed:year |
2000
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pubmed:articleTitle |
Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
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pubmed:publicationType |
Journal Article
|