Linked Life Data

10742152

Source:http://linkedlifedata.com/resource/pubmed/id/10742152

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-6-13
pubmed:abstractText
Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and antibody-dependent pathways. Using a variety of syngenic and xenograft models, we demonstrate here that the inhibitory FcgammaRIIB molecule is a potent regulator of antibody-dependent cell-mediated cytotoxicity in vivo, modulating the activity of FcgammaRIII on effector cells. Although many mechanisms have been proposed to account for the anti-tumor activities of therapeutic antibodies, including extended half-life, blockade of signaling pathways, activation of apoptosis and effector-cell-mediated cytotoxicity, we show here that engagement of Fcgamma receptors on effector cells is a dominant component of the in vivo activity of antibodies against tumors. Mouse monoclonal antibodies, as well as the humanized, clinically effective therapeutic agents trastuzumab (Herceptin(R)) and rituximab (Rituxan(R)), engaged both activation (FcgammaRIII) and inhibitory (FcgammaRIIB) antibody receptors on myeloid cells, thus modulating their cytotoxic potential. Mice deficient in FcgammaRIIB showed much more antibody-dependent cell-mediated cytotoxicity; in contrast, mice deficient in activating Fc receptors as well as antibodies engineered to disrupt Fc binding to those receptors were unable to arrest tumor growth in vivo. These results demonstrate that Fc-receptor-dependent mechanisms contribute substantially to the action of cytotoxic antibodies against tumors and indicate that an optimal antibody against tumors would bind preferentially to activation Fc receptors and minimally to the inhibitory partner FcgammaRIIB.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1078-8956
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10742152-Animals, pubmed-meshheading:10742152-Antibodies, Monoclonal, pubmed-meshheading:10742152-Antibodies, Monoclonal, Humanized, pubmed-meshheading:10742152-Antibodies, Monoclonal, Murine-Derived, pubmed-meshheading:10742152-Antibody-Dependent Cell Cytotoxicity, pubmed-meshheading:10742152-Antigens, CD, pubmed-meshheading:10742152-Antineoplastic Agents, pubmed-meshheading:10742152-Female, pubmed-meshheading:10742152-Humans, pubmed-meshheading:10742152-Immunization, Passive, pubmed-meshheading:10742152-Lymphoma, B-Cell, pubmed-meshheading:10742152-Male, pubmed-meshheading:10742152-Melanoma, Experimental, pubmed-meshheading:10742152-Mice, pubmed-meshheading:10742152-Mice, Inbred BALB C, pubmed-meshheading:10742152-Mice, Nude, pubmed-meshheading:10742152-Receptor, erbB-2, pubmed-meshheading:10742152-Receptors, IgG
pubmed:year
2000
pubmed:articleTitle
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.
pubmed:affiliation
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't