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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5462
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pubmed:dateCreated |
2000-4-11
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pubmed:abstractText |
A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used. We demonstrate two methods that give the required genetic characteristics in an otherwise wild-type genetic background. The first system uses a sex-specific promoter or enhancer to drive the expression of a repressible transcription factor, which in turn controls the expression of a toxic gene product. The second system uses non-sex-specific expression of the repressible transcription factor to regulate a selectively lethal gene product. Both methods work efficiently in Drosophila melanogaster, and we expect these principles to be widely applicable to more economically important organisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Egg Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetracycline,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/YP3 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/msl-2 protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2474-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10741964-Animals,
pubmed-meshheading:10741964-Animals, Genetically Modified,
pubmed-meshheading:10741964-Crosses, Genetic,
pubmed-meshheading:10741964-DNA-Binding Proteins,
pubmed-meshheading:10741964-Drosophila Proteins,
pubmed-meshheading:10741964-Drosophila melanogaster,
pubmed-meshheading:10741964-Egg Proteins,
pubmed-meshheading:10741964-Enhancer Elements, Genetic,
pubmed-meshheading:10741964-Fat Body,
pubmed-meshheading:10741964-Female,
pubmed-meshheading:10741964-Gene Expression Regulation,
pubmed-meshheading:10741964-Genes, Dominant,
pubmed-meshheading:10741964-Genes, Insect,
pubmed-meshheading:10741964-Genes, Lethal,
pubmed-meshheading:10741964-Genes, ras,
pubmed-meshheading:10741964-Homozygote,
pubmed-meshheading:10741964-Male,
pubmed-meshheading:10741964-Models, Biological,
pubmed-meshheading:10741964-Nuclear Proteins,
pubmed-meshheading:10741964-Pest Control, Biological,
pubmed-meshheading:10741964-Promoter Regions, Genetic,
pubmed-meshheading:10741964-Tetracycline,
pubmed-meshheading:10741964-Trans-Activators,
pubmed-meshheading:10741964-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Insect population control using a dominant, repressible, lethal genetic system.
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pubmed:affiliation |
Department of Zoology, Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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