| pubmed-article:10741739 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0238463 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0694890 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0919487 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0543431 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:10741739 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:10741739 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10741739 | pubmed:dateCreated | 2000-6-1 | lld:pubmed |
| pubmed-article:10741739 | pubmed:abstractText | Molecular genetic aberrations and the related phenotypes were investigated in 191 papillary thyroid carcinomas (PTCs) from patients exposed at young age to radioiodine released from the Chernobyl reactor. A high prevalence of RET gene rearrangements (62.3%) with a significant predominance of ELE1/RET (PTC3) over H4/RET (PTC1) rearrangements was found in PTCs of the first post-Chernobyl decade. NTRK1 rearrangements were rare (3.3%). In 3.3%, we observed novel types of RET rearrangements: GOLGA5/ RET (PTC5), HTIF/RET (PTC6), RFG7/RET (PTC7), and an as yet undefined RFGX/RET.RET rearrangements, preferentially ELE1/RET, are related to rapid tumor development. At longer intervals after exposure to ionizing radiation, the prevalence of RET rearrangements declines with a shift from ELE1/RET to H4/RET, most significantly in female patients. The prevalence of specific types of rearrangements is independent of age at irradiation. A significantly higher prevalence of ELE1/RET was observed in the most heavily contaminated Oblasts, Gomel and Brest, suggesting a preferential formation of this type of rearrangement after high thyroid doses. RET rearrangement is related to aggressive growth: Rearrangement-positive PTCs were in a more advanced pT category and more frequently in the pN1 category at presentation than rearrangement-negative PTCs. ELE1/RET is related to the solid variant of PTC, H4/RET more frequently to typical papillary structures. The genotype/phenotype evaluation of post-Chernobyl PTCs reveals a characteristic spectrum of gene rearrangements that lead to typical phenotypes with important biological and clinical implications. | lld:pubmed |
| pubmed-article:10741739 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10741739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741739 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10741739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10741739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741739 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10741739 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10741739 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:LengfelderEE | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:RabesH MHM | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:DemidchikE... | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:SidorovJ EJE | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:KlugbauerSS | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:BeimfohrCC | lld:pubmed |
| pubmed-article:10741739 | pubmed:author | pubmed-author:HoelzelDD | lld:pubmed |
| pubmed-article:10741739 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10741739 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:10741739 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10741739 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10741739 | pubmed:pagination | 1093-103 | lld:pubmed |
| pubmed-article:10741739 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10741739 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10741739 | pubmed:articleTitle | Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. | lld:pubmed |
| pubmed-article:10741739 | pubmed:affiliation | Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany. hm.rabes@lrz.uni-muenchen.de | lld:pubmed |
| pubmed-article:10741739 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10741739 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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