Linked Life Data

10741739

Source:http://linkedlifedata.com/resource/pubmed/id/10741739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-6-1
pubmed:abstractText
Molecular genetic aberrations and the related phenotypes were investigated in 191 papillary thyroid carcinomas (PTCs) from patients exposed at young age to radioiodine released from the Chernobyl reactor. A high prevalence of RET gene rearrangements (62.3%) with a significant predominance of ELE1/RET (PTC3) over H4/RET (PTC1) rearrangements was found in PTCs of the first post-Chernobyl decade. NTRK1 rearrangements were rare (3.3%). In 3.3%, we observed novel types of RET rearrangements: GOLGA5/ RET (PTC5), HTIF/RET (PTC6), RFG7/RET (PTC7), and an as yet undefined RFGX/RET.RET rearrangements, preferentially ELE1/RET, are related to rapid tumor development. At longer intervals after exposure to ionizing radiation, the prevalence of RET rearrangements declines with a shift from ELE1/RET to H4/RET, most significantly in female patients. The prevalence of specific types of rearrangements is independent of age at irradiation. A significantly higher prevalence of ELE1/RET was observed in the most heavily contaminated Oblasts, Gomel and Brest, suggesting a preferential formation of this type of rearrangement after high thyroid doses. RET rearrangement is related to aggressive growth: Rearrangement-positive PTCs were in a more advanced pT category and more frequently in the pN1 category at presentation than rearrangement-negative PTCs. ELE1/RET is related to the solid variant of PTC, H4/RET more frequently to typical papillary structures. The genotype/phenotype evaluation of post-Chernobyl PTCs reveals a characteristic spectrum of gene rearrangements that lead to typical phenotypes with important biological and clinical implications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1093-103
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10741739-Adolescent, pubmed-meshheading:10741739-Age Factors, pubmed-meshheading:10741739-Carcinoma, Papillary, pubmed-meshheading:10741739-Child, pubmed-meshheading:10741739-Child, Preschool, pubmed-meshheading:10741739-Cohort Studies, pubmed-meshheading:10741739-Dose-Response Relationship, Radiation, pubmed-meshheading:10741739-Drosophila Proteins, pubmed-meshheading:10741739-Female, pubmed-meshheading:10741739-Gene Rearrangement, pubmed-meshheading:10741739-Genetic Variation, pubmed-meshheading:10741739-Genotype, pubmed-meshheading:10741739-Humans, pubmed-meshheading:10741739-Infant, pubmed-meshheading:10741739-Infant, Newborn, pubmed-meshheading:10741739-Male, pubmed-meshheading:10741739-Neoplasm Staging, pubmed-meshheading:10741739-Neoplasms, Radiation-Induced, pubmed-meshheading:10741739-Phenotype, pubmed-meshheading:10741739-Proto-Oncogene Proteins, pubmed-meshheading:10741739-Proto-Oncogene Proteins c-ret, pubmed-meshheading:10741739-Radioactive Hazard Release, pubmed-meshheading:10741739-Receptor, trkA, pubmed-meshheading:10741739-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:10741739-Sex Factors, pubmed-meshheading:10741739-Thyroid Neoplasms, pubmed-meshheading:10741739-Time Factors
pubmed:year
2000
pubmed:articleTitle
Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications.
pubmed:affiliation
Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany. hm.rabes@lrz.uni-muenchen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't