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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-6-13
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pubmed:abstractText |
We report an improved single-step synthesis to generate the membrane-permeant acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cells, a model system for acute myelocytic leukemia, in micromolar doses, while the corresponding non-modified cGMP-analogues were inactive.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
571-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10741556-Animals,
pubmed-meshheading:10741556-Antineoplastic Agents,
pubmed-meshheading:10741556-Biotransformation,
pubmed-meshheading:10741556-Cell Death,
pubmed-meshheading:10741556-Cell Line,
pubmed-meshheading:10741556-Cell Membrane Permeability,
pubmed-meshheading:10741556-Cyclic GMP,
pubmed-meshheading:10741556-Humans,
pubmed-meshheading:10741556-Leukemia, Experimental,
pubmed-meshheading:10741556-Leukemia, Myeloid, Acute,
pubmed-meshheading:10741556-Rats,
pubmed-meshheading:10741556-Structure-Activity Relationship,
pubmed-meshheading:10741556-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells.
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pubmed:affiliation |
Zentrum für Umweltforschung und -technologie, Abt. Bioorganische Chemie, Universität Bremen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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