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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
6
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pubmed:dateCreated |
2000-6-13
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|
pubmed:abstractText |
9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10741555-Animals,
pubmed-meshheading:10741555-Antineoplastic Agents,
pubmed-meshheading:10741555-Benzazepines,
pubmed-meshheading:10741555-CDC2 Protein Kinase,
pubmed-meshheading:10741555-Cell Division,
pubmed-meshheading:10741555-Drug Screening Assays, Antitumor,
pubmed-meshheading:10741555-Enzyme Inhibitors,
pubmed-meshheading:10741555-Histones,
pubmed-meshheading:10741555-Humans,
pubmed-meshheading:10741555-Indoles,
pubmed-meshheading:10741555-Oocytes,
pubmed-meshheading:10741555-Starfish,
pubmed-meshheading:10741555-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.
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pubmed:affiliation |
Institut für Pharmazie, Abteilung für Pharmazeutische Chemie, Universität Hamburg, Germany. kunick@chemie.uni-hamburg.de
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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