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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
2000-6-13
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pubmed:abstractText |
A series of cysteine chloromethyl ketone compounds with a systematic variation of the S-alkyl chain length have been synthesized in order to gauge the effect of the alkyl chain length on the cytotoxicity of these compounds against human acute lymphoblastic leukemia cells. Comparable activities were observed for compounds with S-alkyl chains ranging from pentyl to dodecyl, with the best being undecyl (IC50= 1.7 microM) and dodecyl (IC50=2.0 microM) against B-lineage leukemia cells and hexyl (IC50 = 0.7 microM) against T-lineage leukemia cells.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
551-2
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10741551-Alkylation,
pubmed-meshheading:10741551-Antineoplastic Agents,
pubmed-meshheading:10741551-Cell Line,
pubmed-meshheading:10741551-Coloring Agents,
pubmed-meshheading:10741551-Humans,
pubmed-meshheading:10741551-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10741551-Structure-Activity Relationship,
pubmed-meshheading:10741551-Tetrazolium Salts,
pubmed-meshheading:10741551-Thiazoles,
pubmed-meshheading:10741551-Tumor Cells, Cultured,
pubmed-meshheading:10741551-Tumor Suppressor Protein p53
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds.
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|
pubmed:affiliation |
Parker Hughes Cancer Center, Parker Hughes Institute, St. Paul, MN 55113, USA.
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pubmed:publicationType |
Journal Article
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