Source:http://linkedlifedata.com/resource/pubmed/id/10741410
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2000-4-19
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| pubmed:abstractText |
Using a new mAb, 2F1, we characterize a mouse natural killer (NK) cell antigen termed 'killer cell lectin-like receptor G1' (KLRG1; formerly mouse MAFA or 2F1-Ag). KLRG1 is expressed on 30-60% of murine NK cells, and a small fraction of T cells, and is composed of a homodimer of glycosylated 30-38-kDa subunits. Strikingly, cell surface expression of KLRG1 by NK cells was substantially down-regulated in mice deficient for expression of class I molecules, in contrast to the Ly49 lectin-like NK receptors, which are up-regulated in class I-deficient mice. We could not demonstrate binding of KLRG1 to class I molecules in a cell-cell adhesion assay. Transgenic expression of KLRG1 under heterologous transcription elements was unaffected by class I deficiency, indicating that class I molecules do not affect the KLRG1 protein directly, and suggesting that regulation is at the level of expression of the endogenous KLRG1 gene. Evidence is presented that class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Thus, although KLRG1 and Ly49 molecules are both lectin-like inhibitory receptors that are regulated by class I expression, the effects of class I on the cell surface expression of the molecules are opposing, and the underlying regulatory mechanisms are distinct.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, NK Cell Lectin-Like
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
920-30
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10741410-Animals,
pubmed-meshheading:10741410-Antibodies, Monoclonal,
pubmed-meshheading:10741410-Antigens, Ly,
pubmed-meshheading:10741410-Chimera,
pubmed-meshheading:10741410-Down-Regulation,
pubmed-meshheading:10741410-Gene Expression,
pubmed-meshheading:10741410-Histocompatibility Antigens Class I,
pubmed-meshheading:10741410-Killer Cells, Natural,
pubmed-meshheading:10741410-Lectins, C-Type,
pubmed-meshheading:10741410-Membrane Glycoproteins,
pubmed-meshheading:10741410-Mice,
pubmed-meshheading:10741410-Mice, Inbred C57BL,
pubmed-meshheading:10741410-Mice, Knockout,
pubmed-meshheading:10741410-Mice, Mutant Strains,
pubmed-meshheading:10741410-Mice, Transgenic,
pubmed-meshheading:10741410-Receptors, Mitogen,
pubmed-meshheading:10741410-Receptors, NK Cell Lectin-Like,
pubmed-meshheading:10741410-Signal Transduction
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| pubmed:year |
2000
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| pubmed:articleTitle |
NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules.
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| pubmed:affiliation |
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley 94720-3200, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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