Source:http://linkedlifedata.com/resource/pubmed/id/10739068
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9-11
|
| pubmed:dateCreated |
2000-5-11
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| pubmed:abstractText |
Toxicities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were tested on two strains of c-src deficient B6, 129-Src(tm 1 sor) mice, c-src -/+ and c-src -/- and their matched wild-type littermates c-src +/+ mice along with another c-src +/+ mice, from the same genetic lineage, B6, 129-Fos(tm 1 Pa) mice. The most conspicuous effect of c-src deficiency on the toxicity of TCDD appears to be the reduced hepatotoxicity. TCDD-treated c-src deficient mice show only modest degrees of hepatomegaly and triglycerides accumulation as compared to treated wild-type mice.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0045-6535
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1241-6
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:10739068-Animals,
pubmed-meshheading:10739068-Drug-Induced Liver Injury,
pubmed-meshheading:10739068-Hepatomegaly,
pubmed-meshheading:10739068-Liver Diseases,
pubmed-meshheading:10739068-Mice,
pubmed-meshheading:10739068-Mice, Knockout,
pubmed-meshheading:10739068-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:10739068-Tetrachlorodibenzodioxin,
pubmed-meshheading:10739068-Triglycerides
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| pubmed:articleTitle |
Analysis of difference in vivo effects of TCDD between c-src +/+ mice, c-src deficient, -/+ and -/- B6, 129-Src(tm 1 sor) mice and their wild-type littermates.
|
| pubmed:affiliation |
Department of Environmental Toxicology and the Center for Environmental Health Sciences, University of California, Davis 956165, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|