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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2000-4-27
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pubmed:abstractText |
Specific mutations of the p53 tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported from several parts of the world, but to the authors' knowledge to date the status of this gene has not been studied in HCC patients in India, where HCC is one of the major cancers and the frequency of chronic hepatitis B virus (HBV) as well as hepatitis C virus (HCV) infection and exposure to dietary aflatoxin B(1) is very high. The most frequent mutation of the p53 gene in HCC is an AGG(Arg) to AGT(Ser) missense mutation at codon 249 of exon 7.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1565-73
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10738214-Adolescent,
pubmed-meshheading:10738214-Adult,
pubmed-meshheading:10738214-Aged,
pubmed-meshheading:10738214-Carcinoma, Hepatocellular,
pubmed-meshheading:10738214-Case-Control Studies,
pubmed-meshheading:10738214-Child,
pubmed-meshheading:10738214-DNA Mutational Analysis,
pubmed-meshheading:10738214-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10738214-Exons,
pubmed-meshheading:10738214-Female,
pubmed-meshheading:10738214-Genes, p53,
pubmed-meshheading:10738214-Hepatitis B,
pubmed-meshheading:10738214-Humans,
pubmed-meshheading:10738214-India,
pubmed-meshheading:10738214-Liver Neoplasms,
pubmed-meshheading:10738214-Male,
pubmed-meshheading:10738214-Middle Aged,
pubmed-meshheading:10738214-Mutation,
pubmed-meshheading:10738214-Mutation, Missense,
pubmed-meshheading:10738214-Polymerase Chain Reaction,
pubmed-meshheading:10738214-Polymorphism, Single-Stranded Conformational
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pubmed:year |
2000
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pubmed:articleTitle |
P53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India.
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pubmed:affiliation |
Division of Molecular Oncology, Institute of Cytology and Preventive Oncology, Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi, India.
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pubmed:publicationType |
Journal Article
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